Effect of Different Compatibility Proportion of Drug Pair of Ephedrae Herba-Glycyrrhizae Radix et Rhizoma on Plasma Pharmacokinetics of Alkaloids from Ephedrae Herba
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Effect of Different Compatibility Proportion of Drug Pair of Ephedrae Herba-Glycyrrhizae Radix et Rhizoma on Plasma Pharmacokinetics of Alkaloids from Ephedrae Herba
Chinese Journal of Experimental Traditional Medical FormulaeVol. 22, Issue 7, Pages: 100-105(2016)
WEI Ping, ZHENG Fang-hao, HUO Hui-ling, et al. Effect of Different Compatibility Proportion of Drug Pair of Ephedrae Herba-Glycyrrhizae Radix et Rhizoma on Plasma Pharmacokinetics of Alkaloids from Ephedrae Herba[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(7): 100-105.
DOI:
WEI Ping, ZHENG Fang-hao, HUO Hui-ling, et al. Effect of Different Compatibility Proportion of Drug Pair of Ephedrae Herba-Glycyrrhizae Radix et Rhizoma on Plasma Pharmacokinetics of Alkaloids from Ephedrae Herba[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(7): 100-105. DOI: 10.13422/j.cnki.syfjx.2016070100.
Effect of Different Compatibility Proportion of Drug Pair of Ephedrae Herba-Glycyrrhizae Radix et Rhizoma on Plasma Pharmacokinetics of Alkaloids from Ephedrae Herba
Objective: To research change of the content of alkaloids of Ephedrae Herba in plasma after oral administration of different compatibility proportion of drug pair of Ephedrae Herba-Glycyrrhizae Radix et Rhizoma aqueous extracts in rats. Method: Rats were randomly divide into Mahuang (MH) group
MH-GC (12 : 3) group
MH-GC (12 : 6) group and MH-GC (12 : 12) group by weight
plasma samples were collected at different time after drug administration.Plasma samples were treated with liquid-liquid extraction
with amantadine as internal standard
concentrations of norephedrine hydrochloride (NME)
norpseudoephedrine hydrochloride (NMP)
ephedrine hydrochloride (E)
pseudoephedrine hydrochloride (PE)
methylephedrine hydrochloride (ME) in plasma samples at different time were determined by UPLC-MS/MS
DAS 3.0 software was used to calculate pharmacokinetic parameters. Result: Compared with MH group
MRT0-t of NME and NMP were significantly reduced in MH-GC (12 : 3) group
t1/2z and Vz/F of PE had the same trend;AUC0-t of NME
E and PE were significantly increased
CLz/F and Vz/F of PE were significantly reduced in MH-GC (12 : 6) group;MRT0-t of E and PE were significantly extended
CLz/F of ME were significantly increased in MH-GC (12 : 12) group. Conclusion: After compatibility with Glycyrrhizae Radix et Rhizoma
mian pharmacokinetic parameters of five alkaloids in Ephedrae Herba have significant differences.And follow the amount of Glycyrrhizae Radix et Rhizoma
focus of attenuated or efficiency is different.This study demonstrates rationality of ancient prescriptions from pharmacokinetics.
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