Objective: To find new antibacterial compounds

carry out the chemistry research on insect natural products

and find effective antimicrobial sites of insects through pharmacological experiment. Method: The insect bodies were extracted by two stage extraction solvent. Firstly

the bodies were impregnated two times with dichloromethane solvent

and then

soaked with 70% methanol soaking two times. Drug sensitive test was used to qualitatively detect the drugs and their minimum inhibitory concentrations (MIC) were tested by concentration gradient dilution method. Result: Of all eleven species of insects

only extracts (respectively Periostracum cicadae butanol

Mole cricket ethyl acetate

P.cicadae ethyl acetate and P. cicadae water sites) of P. cicadae and the M. cricket have significant antibacterial activity to Staphylococcus aureus and Mycobacterium tuberculosis

and P.cicadae ethyl acetate has the best antibacterial effect against S.aureus. Conclusion :This study will provide new ideas for the discovery of new antibiotics and insects chemical research for development of new medicines.