Objective: To investigate the efficacy of Lidan Paishi Tang in expectant treatment of chronic cholecystitis (liver and qi stagnation syndrome type) and observe its effect on levels of leptin (LEP) and tumor necrosis factor-α (TNF-α). Method: One hundred and twenty chronic cholecystitis patients in our hospital were randomly divided into control group (60 cases) and treatment group (60 cases) according to random number table. By subtracting the shedding and exclusion cases

actually 59 patients in control group and 58 patients in treatment group completed this study. By referring to Chinese consensus on the medical diagnosis and treatment of chronic cholecystitis and gallstones

patients of control group in acute attack period were treated with nitroglycerin tablets (0.5 mg sublingually

1 time/4 hours)

promethazine hydrochloride tablets orally (2 tablets/time

bid).Patients with poor digestion were treated with compound azintamide enteric-coated tablets (2 tablets/time

tid).Those with infection were treated with intravenous drip of piperacillin sodium and tazobactam sodium (4.5 g/time)

diluted by 5% glucose

bid.Metronidazole tablets orally (3 tablets/d

tid). Patients in treatment group were also treated with Lidan Paishi Tang (1 dose/d

bid) based on the treatment in control group. The treatment course was 4 weeks for both groups. The traditional Chinese medicine (TCM) symptom scores

gallbladder wall thickness and gallbladder contract function in two groups were compared before and after treatment.The levels of LEP and TNF-α in serum were detected in two groups. Result: The TCM symptom scores in treatment group were significantly lower than those in control group after treatment (P<0.01). The total efficacy of treatment group was 93.1%

higher than 76.27% in control group (P<0.05). Compared with control group

gallbladder contract function was significantly higher and gallbladder wall thickness was significantly lower in treatment group after treatment (P<0.01). The levels of LEP and TNF-α in serum of treatment group were significantly lower than those of control group after treatment

with statistically significant difference (P<0.01). Conclusion: Lidan Paishi Tang combined with expectant treatment for chronic cholecystitis with liver and qi stagnation syndrome could improve TCM symptom scores

gallbladder contract function

reduce gallbladder wall thickness and levels of LEP and TNF-α in serum and thus increase clinical efficacy.