Objective: To investigate the clinical efficacy of Zhuyu Huoluo detection combined with botulinum toxin A in treating primary trigeminal neuralgia (PTN) (blood stasis resistance type) and observe its effect on levels of 5-hydroxytryptamine (5-HT)

C-reactin protein(CRP) and homocysteic acid (HCY) in serum. Method: One hundred and thirty eligible PTN cases in our hospital were randomly divided into control group and treatment group (65 cases of each group) by random number table. Patients of control group were treated with botulinum toxin A local multipoint injection (2.5-5.0 U/point

40-150 U/time). Based on the treatment of control group

patients in treatment group were also treated with Zhuyu Huoluo detection. Scores of survival quality and visual analogue scale (VAS) were compared between two groups. Clinical efficacy was analyzed after treatment between both groups. Levels of 5-HT

CRP and HCY in serum were detected in two groups. Result: Scores of survival quality in treatment group were significantly lower than those in control group after treatment (P<0.01). Clinical total effective rate of treatment group was 93.85%

higher than 80% in control group(P<0.05). VAS scores in treatment group were significantly lower than those in control group after treatment of 2 and 4 weeks (P<0.01). Level of 5-HT in serum of treatment group was significantly higher than that of control group after treatment while CRP and HCY levels were significantly lower than those in control group(P<0.01). Conclusion: On the basis of western medicine treatment of botulinum toxin A

Zhuyu Huoluo detection in treating PTN of blood stasis resistance type could obviously improve survival quality

decrease VAS scores and improve clinical efficacy

and its mechanism may be associated with reducing levels of HCY and CRP and increasing 5-HT level in serum.