Objective: To observe the effect of Qingzhu detection on cortisol(CS) levels in serum during treatment of adult onset Still's disease(AOSD) (Qi and Yin deficiency and damp-heat blockage type). Method: Totally 60 eligible patients with AOSD from October 2013 to June 2015 were randomly divided into test group (n=30) and control group (n=30). Qingzhu detection

bid for two weeks as a period of treatment was given to 30 patients in test group and diclofenac sodium sustained release tablets (150 mg per day

75 mg · time-1

bid) were given to 30 patients in control group. The treatment course was 2 weeks for both groups. Scores of symptoms and signs were recorded and CS levels in serum were detected before treatment and after treatment. At week 4 and week 8 after treatment

scores of symptoms and signs were also recorded in both test group and control group. Result: Scores of symptoms and signs were significantly improved after treatment in both groups (P<0.01)

and scores in test group were obviously superior to those in control group (P<0.05).CS level in serum was increased in patients of test group after treatment (P<0.05). Improvement degree of symptoms and signs was positively correlated with CS level in serum (r=0.609)

and improvement degree of symptoms had dependence on CS level in serum (P<0.05). According to the follow-up records of symptom and sign scores at week 4 after treatment

test group was significantly superior to control group (P<0.01). Conclusion: Qingzhu detection can effectively control AOSD by improving the level of CS in serum.