Objective: To measure effect exerted by differing microwave drying methods on rehmaionoside A

rehmaionoside D and leonuride in fresh Rehmanniae Radix. Method: Contents of rehmaionoside A

rehmaionoside D and leonuride were determined by HPLC

Aichrombond-AQ C18 column (4.6 mm×250 mm

5 μm)

a mobile phase of acetonitrile-water (5:95) was used

flow rate was 1 mL·min-1

column temperature was set at 30℃

a UV detector was applied with wavelength of 203 nm.Taken freeze drying as a reference

influence of microwave drying on contents of index components in fresh Rehmanniae Radix was investigated. Result: Contents of rehmaionoside A was the highest

which was reached by 5 kW microwave to cut fresh Rehmanniae Radix into slices with thickness of 3-4 mm (0.249 mg·g-1);maximum contents of rehmaionoside D and leonuride were 3.461

6.857 mg·g-1

respectively

which were reached by 3 kW microwave to cut fresh Rehmanniae Radix into slices with thickness of 1-2 mm. Conclusion: Microwave drying method has the biggest effect on the content of leonuride and the smallest effect on contents of rehmaionoside D.Adopting microwave drying method in process of preparing fresh Rehmanniae Radix slices is plausible

which provides technology of concocted processing integration of Radix Rehmanniae with some room for thinking.