HUANG Hui-hui, ZHANG Xiao-yan, SHEN Juan, et al. Investigation of Absorption Characteristics of Anti-inflammatory Effective Parts from Smilacis Chinae Rhizoma in Rat Intestinal Valgus Test[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(8): 96-99.
DOI:
HUANG Hui-hui, ZHANG Xiao-yan, SHEN Juan, et al. Investigation of Absorption Characteristics of Anti-inflammatory Effective Parts from Smilacis Chinae Rhizoma in Rat Intestinal Valgus Test[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(8): 96-99. DOI: 10.13422/j.cnki.syfjx.2016080096.
Investigation of Absorption Characteristics of Anti-inflammatory Effective Parts from Smilacis Chinae Rhizoma in Rat Intestinal Valgus Test
Objective: To investigate absorption characteristics of six components from anti-inflammatory effective parts of Smilacis Chinae Rhizoma. Method: Taking rat everted gut sac model
intestinal sac contents were collected at different time and absorption concentration of polydatin
astilbin
oxyreverstroal
quercitrin
engeletin and resveratrol was determined by HPLC
absorption kinetics parameters were calculated for describing their absorption characters in different intestinal segments (duodenum
jejunum and ileum). Result: Absorption of polydatin in duodenum
jejunum and ileum was no significant difference
while the other five components showed large differences.Absorption of six ingredients showed significant differences in the same intestinal site
their absorptivity at duodenum
jejunum and ileum were 0.85%-2.79%
0.70%-2.73% and 0.90%-1.77%
respectively.Quercitrin showed the highest absorption rate in duodenum and jejunum
polydatin showed the highest absorption rate in ileum.Absorption rate of oxyreverstroal was significantly slower than the other five ingredients
it just showed obvious absorption after 90 min in duodenum. Conclusion: Absorption of polydatin
astilbin
quercitrin
engeletin and resveratrol conforms the first order kinetics
everted gut sac method can evaluate intestinal absorption characteristics of multi-component in Smilacis Chinae Rhizoma extracts.
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