Clinical Effect of Zishen Roujing Decoction in Improving Non-motor Symptoms Liver-Kidney Yin Deficiency Syndrome in Patients with Parkinson's Disease

BAI Yu; LYU Shu-qin; MA Xiao-li

doi:10.13422/j.cnki.syfjx.2016080182

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Clinical Effect of Zishen Roujing Decoction in Improving Non-motor Symptoms Liver-Kidney Yin Deficiency Syndrome in Patients with Parkinson's Disease

更新时间：2024-01-04

- Clinical Effect of Zishen Roujing Decoction in Improving Non-motor Symptoms Liver-Kidney Yin Deficiency Syndrome in Patients with Parkinson's Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 8, Pages: 182-186(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016080182
  CLC： R277.7
- Published：2016
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BAI Yu, LYU Shu-qin, MA Xiao-li. Clinical Effect of Zishen Roujing Decoction in Improving Non-motor Symptoms Liver-Kidney Yin Deficiency Syndrome in Patients with Parkinson's Disease[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(8): 182-186.
DOI：

BAI Yu, LYU Shu-qin, MA Xiao-li. Clinical Effect of Zishen Roujing Decoction in Improving Non-motor Symptoms Liver-Kidney Yin Deficiency Syndrome in Patients with Parkinson's Disease[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(8): 182-186. DOI： 10.13422/j.cnki.syfjx.2016080182.

摘要

目的: 探讨滋肾柔经汤改善帕金森病(PD)非运动症状肝肾阴虚证的临床疗效以及对血清脂联素(APN)

尿酸(UA)

肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平的影响。方法: 选择符合条件的108例患者

按随机数字表法分为对照组和治疗组

各54例;对照组给予美多巴片治疗

首次用量为1片/次

tid;治疗组在对照组用药基础上采取滋肾柔经汤治疗

常规水煎2次

分早晚口服;两组患者疗程均12周。比较两组中医临床症状评分

非运动症状筛查问卷(NMSQuest)评分

帕金森病睡眠量表(PDSS)评分和汉密尔顿抑郁量表(HAMD)评分;分析两组疗后12周的疗效;检测两组血清APN

TNF-α

IL-6水平。结果: 治疗组治疗后中医症状评分均显著低于对照组(P<0.01);治疗组的总有效率为87.04%

对照组为68.52%

治疗组明显高于对照组(P<0.05);治疗组治疗后NMSQuest

HAMD评分显著低于对照组

PDSS评分显著高于对照组(P<0.01);治疗后6

12周

治疗组患者血清APN和UA水平均高于同期对照组

而TNF-α

IL-6显著低于对照组(P<0.01)。结论: 在西药治疗基础上

滋肾柔经汤改善帕金森非运动症状肝肾阴虚证可显著改善中医症状和非运动症状

提高临床疗效

上调血清APN

UA水平

下调TNF-α

IL-6水平可能在其中发挥重要作用。

Abstract

Objective: To investigate the clinical efficacy of Zishen Roujing decoction in improving non-motor symptoms liver-kidney Yin deficiency syndrome in patients with Parkinson's disease

and explore its effect on adiponectin (APN)

uric acid(UA)

tumor necrosis factor (TNF)-α

and interleukin(IL)-6 levels. Method: One hundred and eight eligible cases were selected and randomly divided into control group and treatment group according to random number table

54 cases in each group. Patients in control group were treated with madopar tablets

1 tablet/time and tid. Based on the treatment in control group. Patients in treatment group also received Zishen Roujing decoction

1 dose/d and bid. The treatment course was 12 weeks for all patients. Scores of traditional Chinese medicine (TCM) symptoms

scores of non-motor symptoms questionnaire (NMSQuest)

scores of parkinson disease sleep scale (PDSS)

and scores of hamilton depression scale (HAMD) were compared between two groups. Clinical efficacy was analyzed between two groups after 12 weeks' treatment. The levels of APN

TNF-α

and IL-6 in serum were detected in both groups. Result: After treatment

TCM symptom scores in treatment group were significantly lower than those of control group (P<0.01). Total effective rate was 87.04% in treatment group

significantly higher than 68.52% in control group (P<0.05). Scores of NMSQuest and HAMD in treatment group were significantly lower than those of control group

and PDSS scores were significantly higher than those of control group after treatment (P<0.01). After 6 and 12 weeks' treatment

Levels of APN and UA in serum of treatment group were higher

while TNF-α and IL-6 levels were significantly lower than those of control group (P<0.01). Conclusion: Based on western medicine

Zishen Roujing decoction in improving non-motor symptoms liver-kidney Yin deficiency syndrome in patients with Parkinson's disease could remarkably improve TCM symptoms and non-motor symptoms

and enhance clinical efficacy. Its mechanism may be associated with up-regulating APN and UA levels and down-regulating TNF-α

and IL-6 levels in serum.

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