Clinical Observation of Yangzheng Xiaoji Capsule in Treatment of Cancer Cachexia

BI Jun-fang; MA Xiao-li; ZHANG Hua

doi:10.13422/j.cnki.syfjx.2016080204

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Clinical Observation of Yangzheng Xiaoji Capsule in Treatment of Cancer Cachexia

更新时间：2024-01-04

- Clinical Observation of Yangzheng Xiaoji Capsule in Treatment of Cancer Cachexia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 8, Pages: 204-207(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016080204
  CLC： R273
- Published：2016
- 稿件说明：
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BI Jun-fang, MA Xiao-li, ZHANG Hua. Clinical Observation of Yangzheng Xiaoji Capsule in Treatment of Cancer Cachexia[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(8): 204-207.
DOI：

BI Jun-fang, MA Xiao-li, ZHANG Hua. Clinical Observation of Yangzheng Xiaoji Capsule in Treatment of Cancer Cachexia[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(8): 204-207. DOI： 10.13422/j.cnki.syfjx.2016080204.

摘要

目的: 观察养正消积胶囊治疗癌症恶病质的近期疗效及安全性

为临床治疗癌症恶病质提供相应依据。方法: 将70例癌症恶病质患者随机分为观察组和对照组

每组各35例;两组患者均给予饮食指导及一般营养支持治疗

观察组加用养正消积胶囊

4粒/次

口服3次/d;对照组加用醋酸甲地孕酮分散片

160 mg/次

口服1次/d;观察周期1个月;观察治疗前后两组患者中医症状、进食量和上臂中部周径的变化

对生活质量(QOL)进行评分

并检测血清白蛋白、外周血红蛋白及T淋巴细胞亚群水平和不良反应。结果: 治疗后观察组中医症状疗效及进食量疗效均优于对照组(P<0.05);治疗后

观察组和对照组患者上臂中部周径分别为(24.58±2.21)

(24.01±2.29) cm

较治疗前均增加(P<0.05)

但两组比较无明显差异;治疗后观察组和对照组患者QOL评分分别为(36.52±3.39)

(34.80±3.46)分

较治疗前亦均有增加(P<0.05

P<0.01)

但观察组QOL评分较对照组增加更显著(P<0.05);两组恶病质患者外周血红蛋白

血清白蛋白及CD3+

CD4+

CD8+

CD4+/CD8+细胞水平较治疗前均有改善(P<0.05

P<0.01)

且观察组上述指标的改善优于对照组(P<0.05);观察组无不良反应发生。结论: 养正消积胶囊能够显著改善癌症恶病质患者的中医症状

增进食量

提高生活质量

还可显著改善患者的血清白蛋白、外周血红蛋白及T淋巴细胞亚群水平

与甲地孕酮分散片比较

具有更好的临床疗效

且安全性好

值得临床进一步深入研究与应用。

Abstract

Objective: To observe the short-term effect amd safety of Yangzheng Xiaoji capsule in the treatment of cancer cachexia

and provide theory basis for its clinical treatment. Method: Totally 70 patients with cancer cachexia were randomly divided into observation group and control group

35 cases in each group. Patients of both groups received diet guidance and general nutrition support. Patients in observation group also orally took Yangzheng Xiaoji capsules

4 tablets/time

3 times/d;while the patients in control group orally took megestrol acetate tablets

160 mg/time

1 time/d. Observation period lasted for 1 month. Traditional Chinese medicine (TCM) symptom scores

food-intake and middle upper arm circumference of both groups were observed before and after treatment. Quality of life (QOL) was graded

and the level of serum albumin

hemoglobin

T lymphocyte subsets and adverse reactions were also detected. Result: After treatment

the TCM symptom efficacy and food-intake in the observation group were superior to those in the control group (P<0.05). After treatment

middle upper arm circumference of patients in the observation group and control group were (24.58±2.21) score and (24.01±2.29) score respectively

with an increase as compared with those before treatment

but there was no statistically significant difference between two groups. The QOL score was (36.52±3.39)score and (34.80±3.46)score for observation group and control group respectively

with an increase as compared with those before treatment

but the improvement of QOL score in observation group was more significant than that of control group (P<0.05). The levels of serum albumin

hemoglobin and CD3+

CD4+

CD8+

CD4+/CD8+ cells were significantly improved after treatment in both groups (P<0.01

P<0.05). However

the improvement in the observation group was more significant than that in control group after treatment (P<0.05).There was no adverse reaction in the observation group. Conclusion: Yangzheng Xiaoji capsule could effectively improve TCM symptoms for patients with cancer cachexia

increase food-intake

improve quality of life and significantly improve serum albumin

hemoglobin and T lymphocyte subsets level. It is much more better than megestrol acetate in clinical efficacy and safety. Yangzheng Xiaoji capsule deserves much more clinical research and application.

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