Network Meta-analysis of Chinese Medicine Injections Combined with Transcatheter Arterial Chemoembolization for Liver Cancer

SHI Fang-yu; LOU Li-li; XIE Wen; LI Qian-ru; ZHANG Pan; GE Long; TIAN Jin-hui

doi:10.13422/j.cnki.syfjx.201608100180

您当前的位置：

首页 >

文章列表页 >

Network Meta-analysis of Chinese Medicine Injections Combined with Transcatheter Arterial Chemoembolization for Liver Cancer

更新时间：2024-01-04

- Network Meta-analysis of Chinese Medicine Injections Combined with Transcatheter Arterial Chemoembolization for Liver Cancer
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 10, Pages: 180-187(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.201608100180
  CLC： R735.7
- Published：2016
- 稿件说明：
移动端阅览
SHI Fang-yu, LOU Li-li, XIE Wen, et al. Network Meta-analysis of Chinese Medicine Injections Combined with Transcatheter Arterial Chemoembolization for Liver Cancer[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(10): 180-187.
DOI：

SHI Fang-yu, LOU Li-li, XIE Wen, et al. Network Meta-analysis of Chinese Medicine Injections Combined with Transcatheter Arterial Chemoembolization for Liver Cancer[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(10): 180-187. DOI： 10.13422/j.cnki.syfjx.201608100180.

摘要

目的: 采用网状Meta分析评价不同中药注射剂联合肝动脉插管栓塞化疗术(TACE)治疗肝癌的有效性和安全性。方法: 计算机检索PubMed

The Cochrane Library

EMBASE

CBM

CNKI

万方和维普数据库

检索时间均从建库起截止2015年3月

纳入中药注射剂联合TACE对比单纯TACE治疗肝癌的随机对照试验(RCTs)

并按预先制定的纳入与排除标准筛选和纳入文献

由2名研究者独立对纳入的RCTs进行数据提取和质量评价

采用WinBugs 1.4软件对数据进行贝叶斯网状Meta分析。结果: 最终纳入91个RCTs

共计6 493例患者

网状Meta分析结果显示:7种中药注射剂联合TACE对比单独TACE治疗方案在提高肝癌治疗的有效率和患者的生活质量、降低呕心呕吐、肝功能异常和白细胞减少发生率方面均显示出其优越性;在治疗肝癌的有效性方面康艾+TACE

复方苦参+TACE

艾迪+TACE

康莱特+TACE

华蟾素+TACE和鸦胆子油乳+TACE的疗效优于黄芪多糖+TACE

而其他注射液+TACE之间的差异无统计学意义;在提高生活质量方面复方苦参+TACE比艾迪+TACE更具优势;而在减少恶心呕吐和白细胞的发生率方面7种注射液+TACE之间均无统计学意义。结论: 网状Meta分析的结果表明

7种中药注射剂联合TACE治疗肝癌的疗效和安全性均优于单独TACE疗法

且根据概率排序结果显示:在提高有效率方面

康艾联合TACE较其他种6中药联合TACE相对有效

而在改善生活质量情况方面

华蟾素注射液联合TACE较其他6种药联合TACE相对有效。

Abstract

Objective: To assess the clinical effects and safety of Chinese medicine injection combined with transcatheter arterial chemoembolization (TACE) for liver cancer by using network Meta-analysis. Method: The randomized controlled trials (RCTs) of Chinese medicine injections (CMIs) combined with TACE VS TACE alone for liver cancer were searched from PubMed

The Cochrane Library

EMBASE

CBM

Chinese Knowledge Infrastructure (CNKI)

Wanfang

and Chinese Scientific Journals Fulltext Database (VIP-CSJFD)

up to March 2015 since database establishment. The RCTs were screened and selected according to the predefined inclusion and exclusion criteria Data extraction and quality evaluation were done for the included RCTs by 2 independent researchers

and Bayesian network meta-analysis was done by using WinBugs 1.4 software. Result: The 91 RCTs including 6 493 patients were finally included. The results of network Meta-analysis showed that 7 kinds of CMIs combined with TACE were superior to TACE alone in the treatment of liver cancer in increasing effective rate and life quality

reducing nausea and vomiting

abnormal liver function and leukopenia incidence. In terms of efficacy for liver cancer

Kang'ai injection+TACE

Fufang Kushen injection+TACE

Aidi injection+TACE

Kanglaite injection+TACE

cinobufagin injection+TACE

and bruceolic oil emulsion injection+TACE were superior to astragalus polysaccharide injection+TACE

whereas there was no statistically significant difference with other injections+TACE. In terms of improving life quality

Fufang Kushen injection+TACE was prior to Aidi injection+TACE. There was no statistically significant difference among the 7 CHIs in reducing the incidence of nausea

vomiting and leukopenia. Conclusion: Based on the results of network Meta-analysis

7 CHIs combined with TACE have better efficacy and safety than TACE alone for liver cancer. Based on the probability ranking results

Kang'ai injection+TACE is more effective as compared with other 6 CHIs+TACE for increasing effective rate

and cinobufagin injection+TACE is more effective as compared with other 6 CHIs+TACE for improving the quality of life.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Treatment of Liver Cancer by Intervening TGF-β Signaling Pathway with Traditional Chinese Medicine： A Review

Berbamine Hydrochloride Ameliorates Sorafenib Resistance by Regulating Autophagy and PI3K/Akt/mTOR Signaling Pathway

Intervention Mechanism of Biejiajian Wan on Primary Liver Cancer by Regulating lncRNA SNHG5/miRNA-26a-5p/GSK-3β Signal Axis

Effect of Compound Phyllanthus urinaria Ⅱ on Growth and Expression of miR-122 and IGF-1R of Hepatocellular Carcinoma Hep3B Cells in Nude Mice

Anti-liver Cancer Mechanisms of Biejiajian Wan and Clinical Research： A Review

Related Author

CHENG Hao

GUO Haohao

SUN Jun

XUE Juan

JI Chunyan

LI Shiyi

DING Yuxue

YUE Huaqiang

Related Institution

Hubei Provincial Hospital of Integrated Chinese & Western Medicine

Gansu University of Chinese Medicine

First Clinical College，Hubei University of Chinese Medicine

School of Basic Medical Sciences,Guangzhou University of Chinese Medicine

School of Life Sciences and Technology,Tongji University

AI问答

Address：No. 16, Nanxiaojie, Dongzhimennei, Beijing Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰