Clinical Analysis of Longdan Xiegan Tang Combined with Ditan Tang in Treatment of Epilepsy Attack with Syndrome of Phlegm-fire Disturbing Spirit

CAO Yong; ZHENG Hui-jun; FAN Lu-ding; ZHANG Xin-chang

doi:10.13422/j.cnki.syfjx.2016090172

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Clinical Analysis of Longdan Xiegan Tang Combined with Ditan Tang in Treatment of Epilepsy Attack with Syndrome of Phlegm-fire Disturbing Spirit

更新时间：2024-01-04

- Clinical Analysis of Longdan Xiegan Tang Combined with Ditan Tang in Treatment of Epilepsy Attack with Syndrome of Phlegm-fire Disturbing Spirit
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 9, Pages: 172-176(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016090172
  CLC： R277.7
- Published：2016
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CAO Yong, ZHENG Hui-jun, FAN Lu-ding, et al. Clinical Analysis of Longdan Xiegan Tang Combined with Ditan Tang in Treatment of Epilepsy Attack with Syndrome of Phlegm-fire Disturbing Spirit[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(9): 172-176.
DOI：

CAO Yong, ZHENG Hui-jun, FAN Lu-ding, et al. Clinical Analysis of Longdan Xiegan Tang Combined with Ditan Tang in Treatment of Epilepsy Attack with Syndrome of Phlegm-fire Disturbing Spirit[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(9): 172-176. DOI： 10.13422/j.cnki.syfjx.2016090172.

摘要

目的: 探讨龙胆泻肝汤和涤痰汤加减治疗癫痫发作期痰火扰神证的临床疗效以及对患者抗氧化应激的影响。方法: 本组完成研究病例共107例

按数字表法随机分为治疗组52例和对照组55例;两组均参照《临床诊疗指南·癫痫病分册》给予推荐药物治疗;治疗组在用药的基础上给予龙胆泻肝汤和涤痰汤加减内服

1剂/d

常规水煎煮2次

分早晚服用。所有患者均连续治疗12周。记录两组治疗前后癫痫发作频次和持续时间;参照癫痫患者生活质量评价表(QOLIE-31)比较两组患者生活质量;检测两组血清总超氧化物歧化酶(SOD)

还原型谷胱甘肽(GSH)

谷胱甘肽过氧化物酶(GSH-Px)和丙二醛(MDA)水平。结果: 治疗组治疗后癫痫发作频次和持续时间均明显低于对照组(P<0.01);治疗组临床总有效率为88.46%

对照组为70.91%

治疗组高于对照组(P<0.05);治疗组治疗后生活质量各指标评分均明显高于对照组(P<0.01);治疗后治疗组血清SOD

GSH和GSH-Px均高于对照组

而MDA明显低于对照组

比较差异均有统计学意义(P<0.01)。结论: 在常规西药治疗的基础上

采用龙胆泻肝汤和涤痰汤加减治疗癫痫发作期痰火扰神证可明显减少癫痫发作频次和持续时间

改善患者生活质量

提高临床治疗效果

增强机体抗氧化应激能力可能与其发挥上述治疗效果相关。

Abstract

Objective: To discuss the curative effect of Longdan Xiegan Tang combined with Ditan Tang in treatment of epilepsy attack with syndrome of phlegm-fire disturbing spirit and investigate its influences on anti-oxidative stress of patients. Method: One hundred and seven cases were included in this study and were randomly divided into treatment group (52 cases) and control group(55 cases) according to random number table. Patients in both groups received therapy of the recommended drugs with reference to The Clinical Diagnosis and Treatment Guidelines of Epilepsy. The patients in treatment group also received Longdan Xiegan Tang combined with Ditan Tang (1 dose/d

bid) on the basis of treatment in control group. The treatment course was 12 weeks for both groups. Epileptic seizure frequency and time of duration were recorded in two groups pre-post treatment. Quality of life was compared between two groups with reference to Quality of Life in Epilepsy (QOLIE-31). Total superoxide dismutase (SOD)

reduced glutathione (GSH)

glutathione peroxidase(GSH-Px) and malondialdehyde (MDA) levels in serum were detected in two groups. Result: Epileptic seizure frequency and time of duration in treatment group were significantly lower than those of control group after treatment (P<0.01). The total effective rate 88.46% in treatment group

significantly higher than 70.91% in control group (P<0.05). Every index score of QOLIE-31 in treatment group was obviously higher than that of control one after treatment (P<0.01). The levels of SOD

GSH and GSH-Px in serum of treatment group were significantly higher than those of control group

while MDA level was significantly lower than that of control group after treatment

with statistically significant differences (P<0.01). Conclusion: Longdan Xiegan Tang combined with Ditan Tang based on western medicine in treatment of epilepsy attack with syndrome of phlegm-fire disturbing spirit could evidently reduce epileptic seizure frequency and time of duration

improve quality of life and curative effect for the patients. The effect may be related to increasing anti-oxidative stress capacity.

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