Objective: To discuss the curative effect of Longdan Xiegan Tang combined with Ditan Tang in treatment of epilepsy attack with syndrome of phlegm-fire disturbing spirit and investigate its influences on anti-oxidative stress of patients. Method: One hundred and seven cases were included in this study and were randomly divided into treatment group (52 cases) and control group(55 cases) according to random number table. Patients in both groups received therapy of the recommended drugs with reference to The Clinical Diagnosis and Treatment Guidelines of Epilepsy. The patients in treatment group also received Longdan Xiegan Tang combined with Ditan Tang (1 dose/d

bid) on the basis of treatment in control group. The treatment course was 12 weeks for both groups. Epileptic seizure frequency and time of duration were recorded in two groups pre-post treatment. Quality of life was compared between two groups with reference to Quality of Life in Epilepsy (QOLIE-31). Total superoxide dismutase (SOD)

reduced glutathione (GSH)

glutathione peroxidase(GSH-Px) and malondialdehyde (MDA) levels in serum were detected in two groups. Result: Epileptic seizure frequency and time of duration in treatment group were significantly lower than those of control group after treatment (P<0.01). The total effective rate 88.46% in treatment group

significantly higher than 70.91% in control group (P<0.05). Every index score of QOLIE-31 in treatment group was obviously higher than that of control one after treatment (P<0.01). The levels of SOD

GSH and GSH-Px in serum of treatment group were significantly higher than those of control group

while MDA level was significantly lower than that of control group after treatment

with statistically significant differences (P<0.01). Conclusion: Longdan Xiegan Tang combined with Ditan Tang based on western medicine in treatment of epilepsy attack with syndrome of phlegm-fire disturbing spirit could evidently reduce epileptic seizure frequency and time of duration

improve quality of life and curative effect for the patients. The effect may be related to increasing anti-oxidative stress capacity.