Objective: To investigate the efficacy of Fuzi Lizhong Tang plus Sishen Wan in treating diarrhea type irritable bowel syndrome (IBS-D) with spleen and kidney deficiency syndrome and observe its effect on protease activated receptor 2 (PAR2)and PAR4 of mucous membrane of rectum. Method: One hundred and twenty IBS-D patients were randomly divided into treatment group (60 cases) and control group (60 cases) according to random number table. All cases were given with non-drug therapy referring to Diagnosis and Treatment Plan of Integrated Chinese and Western Medicine for Irritable Bowel Syndrome. Patients of control group also orally received bacillus subtilis and enterococcus faecium enteric-coated capsules

2 tablets/time and bid. While the patients of treatment group were also given with Fuzi Lizhong Tang plus Sishen Wan

1dose/d and bid. The treatment course was 6 weeks for both groups. The clinical symptom scores

stool property score

and defecation were compared between two groups. PAR2 and PAR4 levels of mucous membrane of rectum were detected for two groups. Result: The clinical symptom scores in treatment group were significantly lower than those in control group after treatment (P<0.01). The clinical efficacy was 96.67% and 83.33% respectively in treatment group and control group

with statistically significant difference between two groups (P<0.05). Scores of stool property and days for defecation urgency within 10 days in treatment group were significantly decreased after treatment (P<0.01). After treatment

PAR2 and PAR4 levels of mucous membrane of rectum in treatment group were lower than those in control group

with statistically significant difference (P<0.01). Conclusion: Fuzi Lizhong Tang plus Sishen Wan in treatment of IBS-D with spleen and kidney deficiency can decrease symptom scores

improve defecation

enhance clinical efficacy

and down-regulate PAR2 and PAR4 levels of mucous membrane of rectum.