Objective: To observe the efficacy of integrated Chinese and western medicine on knee osteoarthritis (KOA) with syndrome of cold-dampness blocking collaterals and investigate its effect on stromal cell derived factor 1(SDF-l) and Irisin. Method: One hundred and fourteen cases with KOA patients were divided into control group (56 cases) and treatment group (58 cases) according to visiting sequence referring to random number table. Patients in control group were given with glucosamine hydrochloride tablets (2 tablets/time

3 times/d) and self management training (1 time/week and 2 h/time). Based on the treatment of control group

the patients in treatment group were also given with mustard seed powder point application (3-5 h/time and 1 time/week) and manipulative therapy (30 min/time and 1 time/d). All patients were treated for 6 weeks. Scores of the Western Ontario and McMaster Universities (WOMAC)

qualify of life

and clinical efficacy were compared between two groups. SDF-1 and Irisin levels in serum and synovial fluid were detected in both groups. Result: Scores of various indexes of WOMAC scale and total score in treatment group were significantly lower than those in control group after treatment (P<0.01). Scores of all indexes of SF-36 scale in treatment group were higher than those in control group (P<0.01). Ridit analysis showed that the treatment group was superior to control group in clinical efficacy (P<0.05). After treatment

SDF-l levels in serum and synovial fluid in treatment group were significantly lower than those in control group

while Irisin level was significantly higher that of control group (P<0.01). Conclusion: Efficacy of integrated Chinese and western medicine on knee osteoarthritis with syndrome of cold-dampness blocking collaterals is exact

and the mechanism may be related to inhibiting SDF-1 level in serum and synovial fluid and up-regulation of Irisin.