LIU Hong, FAN Xin-sheng. Network Pharmacology on Interaction of Effective or Toxic Components of Kansui Radix and Glycyrrhizae Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(9): 186-192.
DOI:
LIU Hong, FAN Xin-sheng. Network Pharmacology on Interaction of Effective or Toxic Components of Kansui Radix and Glycyrrhizae Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(9): 186-192. DOI: 10.13422/j.cnki.syfjx.2016090186.
Network Pharmacology on Interaction of Effective or Toxic Components of Kansui Radix and Glycyrrhizae Radix et Rhizoma
Objective: To explore the molecular mechanisms of effective or toxic components of Kansui Radix and Glycyrrhizae Radix et Rhizoma by using network pharmacology method
and to investigate the correlations between multi-compounds
multi-targets and multi-pathways. Method: The main effective or toxic components of Kansui Radix and Glycyrrhizae Radix et Rhizoma
including kansuinine A
kansuinine B
kansuinine C
gycyrrhizic acid
liquiritin
isoliquiritin
formononetin were collected to build multi-components-proteins networks based on PharmMappear database. The obtained targets information was used to obtain corresponding pathways by using Boao MAS 3.0 system
and then Cytoscape software was used to construct components-targets-pathways network model. Result: The network analysis showed that
action of the effective or toxic components of Kansui Radix and Glycyrrhizae Radix et Rhizoma involved 61 pathways related to nerve-immune-endocrine-urinary. Contrary to their efficacy in adjusting water and electrolyte excretion
they were related with renin-angiotensin system
steroids biosynthesis and other pathways. Kansui Radix and Glycyrrhizae Radix et Rhizoma had synergistic effects in anti-tumor
anti-inflammatory and immune regulation
covering 33 pathways. Compatibility of Kansui Radix and Glycyrrhizae Radix et Rhizoma would enhance toxicity concerned to inhibition or induction of hepatic drug enzyme. Conclusion: Compatibility of Kansui Radix and Glycyrrhizae Radix et Rhizoma could result in decreased or synergistic effect and would change the toxicity. This reflected the compatibility mode of multi-compounds
multi-targets and multi-pathways for traditional Chinese medicines. It may provide reference for deeper study on molecular mechanism of compatibility of Kansui Radix and Glycyrrhizae Radix et Rhizoma.
Mechanism of Platycodonis Radix-Glycyrrhizae Radix et Rhizoma Based on Network Pharmacology
Metabolomics-based Analysis of Toxicity Changes of Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma in Sinitang Before and After Compatibility
Effect of Kansui Radix and Glycyrrhizae Radix et Rhizoma in Gansui Banxiatang on CYP450 Enzyme in Ascites Rats
Pharmacological Effect of Glycyrrizae Radix et Rhizoma Compatibility and Its Mechanism
Explore Effective Constituents and Mechanism of Tingli Dazao Xiefeitang in Treatment of Heart Failure Based on Network Pharmacology and Mass Spectrometry
Related Author
WU Jia-rui
JIN Yan-ping
DUAN Xiao-jiao
LIU Shi
ZHANG Bing
PENG Wei
LIU Dongmei
FU Shu
Related Institution
School of Pharmacy,Chengdu University of Traditional Chinese Medicine
Sichuan Province Orthopedic Hospital
Zigong First People's Hospital
Beijing University of Chinese Medicine
ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research,Guangxi University of Chinese Medicine