Relationship Between PI3K/Akt Signaling Pathway and Vascular Dementia and Traditional Chinese Medicine Intervention

ZHU Jin-qiang; SONG Wan-shan; MA Yan; QIN Xiu-de

doi:10.13422/j.cnki.syfjx.2016090223

您当前的位置：

首页 >

文章列表页 >

Relationship Between PI3K/Akt Signaling Pathway and Vascular Dementia and Traditional Chinese Medicine Intervention

更新时间：2024-01-04

- Relationship Between PI3K/Akt Signaling Pathway and Vascular Dementia and Traditional Chinese Medicine Intervention
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 9, Pages: 223-229(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016090223
  CLC： R285
- Published：2016
- 稿件说明：
移动端阅览
ZHU Jin-qiang, SONG Wan-shan, MA Yan, et al. Relationship Between PI3K/Akt Signaling Pathway and Vascular Dementia and Traditional Chinese Medicine Intervention[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(9): 223-229.
DOI：

ZHU Jin-qiang, SONG Wan-shan, MA Yan, et al. Relationship Between PI3K/Akt Signaling Pathway and Vascular Dementia and Traditional Chinese Medicine Intervention[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(9): 223-229. DOI： 10.13422/j.cnki.syfjx.2016090223.

摘要

血管性痴呆(vascular dementia

VaD)的临床表现主要包括脑血管病变和认知功能障碍

其发生、发展与脑血流量和神经元存活状态密切相关。研究表明

磷酸肌醇3-激酶(phosphoinositide 3-kinase

PI3K)/蛋白激酶B(protein kinase

PKB/Akt)信号通路广泛存在各种细胞中

在脑微血管内皮细胞(brain microvascular endothelial cells

BMEC)中可以通过下游内皮型一氧化氮合酶(endothelial nitric oxide synthase

eNOS)/一氧化氮(nitric oxide

NO)途径调节血管舒缩功能及脑血流量;在神经元中可以对抗神经元凋亡

促进神经元存活

是VaD发生、发展过程的重要环节之一。到目前为止

一些研究发现部分中药、有效成分及复方可通过激活PI3K/Akt信号通路而发挥神经保护作用

有必要对该方面研究进展做一综述

以期为今后深入研究提供参考。

Abstract

The major clinical manifestations of vascular dementia (VaD) include cerebrovascular accidents and cognitive dysfunction

whole occurrence and development are closely related to the cerebral blood flow and neuron survival state. Studies have shown that the phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB/Akt) signaling pathway widely exist in various cells. In brain microvascular endothelial cells (BMEC)

it can regulate the vasomotor function and cerebral blood flow through downstream endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway;in neurons

it can promote neuronal survival against neuronal apoptosis

which is one of the important parts in the occurrence and development of VaD. So far

some studies have shown that traditional Chinese medicine

active ingredients and compounds can play the neuroprotective effect through the activation of PI3K/Akt signaling pathway. In order to provide reference for further in-depth study in the future

it is necessary to make a review on the research progress in this filed.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Prevention and Treatment of Colorectal Cancer Through Traditional Chinese Medicine Targeted Wnt Signaling Pathway： A Review

Regulation of Ferroptosis by Traditional Chinese Medicine for Colorectal Cancer Intervention： A Review

TCM Intervention in Prostate Cancer via Wnt/β-catenin Signaling Pathway： A Review

Traditional Chinese Medicine Intervention in Diabetic Nephropathy Based on PI3K/Akt Signaling Pathway： A Review

Intervention of Acute Lung Injury by Traditional Chinese Medicine via Regulating Oxidative Stress： A Review

Related Author

SHEN Jialin

ZHAO Xiaoying

XUE Chengcheng

LYU Yi

SHI Shang

MA Yuyuan

ZHOU Cheng

YANG Lin

Related Institution

Shaanxi University of Chinese Medicine

The Affiliated Hospital of Shaanxi University of Chinese Medicine

Changzhou Hospital of Traditional Chinese Medicine（TCM）

Xianyang Central Hospital

Shuguang Hospital Affiliated to Shanghai University of TCM

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰