DUAN Wei-bin, WANG Hui. Investigation of Promoting Effects of Some Penetration Enhancers by Entropy Weight Fuzzy Comprehensive Evaluation Model[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(10): 1-5.
DOI:
DUAN Wei-bin, WANG Hui. Investigation of Promoting Effects of Some Penetration Enhancers by Entropy Weight Fuzzy Comprehensive Evaluation Model[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(10): 1-5. DOI: 10.13422/j.cnki.syfjx.2016100001.
Investigation of Promoting Effects of Some Penetration Enhancers by Entropy Weight Fuzzy Comprehensive Evaluation Model
Objective: To investigate whether entropy weight fuzzy comprehensive evaluation method is feasible for study on promoting effects of some kinds of penetration enhancers and to provide a reliable evaluation method for penetration enhancers. Method: Diclofenac sodium was used as model drug
azone
volatile oil from Citri Reticulatae Pericarpium
eucalyptus oil
menthol and borneol were tested as transdermal enhancers
taking isolated skin of SD rats as transdermal barrier
transdermal experiments were carried by a modified Franz diffusion cell.The content of diclofenac sodium was measured by HPLC with mobile phase of methanol-water-acetic acid (80: 20: 0.5) and detection wavelength at 276 nm.Permeability coefficient
lag time
steady flow and enhancement ratio were calculated.Effects of penetration enhancers were evaluated by entropy weight fuzzy comprehensive evaluation method. Result: Penetration enhancers had penetration enhancing effect on diclofenac sodium with different degrees.Azone
menthol and borneol had the best significant promoting effects whose maximum memberships were 0.761 1
0.582 1 and 0.495 4;volatile oil from Citri Reticulatae Pericarpium and eucalyptus oil had certain promoting effects whose maximum memberships were 0.454 2 and 0.480 9. Conclusion: Entropy weight fuzzy comprehensive evaluation method is feasible for evaluating promoting effects of penetration enhancers.
Analyzing Differences in Volatile Components of Citri Reticulatae Pericarpium Before and After Being Stir-fried with Halloysitum Rubrum Based on HS-GC-MS and Intelligent Sensory Technology
Analysis of Chemical Components and Tissue Distribution of Lujiao Formula Based on UPLC-Q-Orbitrap-MS
Quality Difference Analysis of Raw and Steamed Products of Citri Reticulatae Pericarpium Based on Electronic Eye Technique and Chemical Fingerprint
Analysis on Components Absorbed into Blood of Citri Reticulatae Pericarpiumin RatsBased on Sequential Metabolism and UPLC-HRMS
Processing ofCitri Reticulatae Pericarpium: A Review
Related Author
XIN Li
WEN Jiawen
GONG Wenhui
ZHAO Beibei
YAN Shihao
CHEN Huashi
LE Haiping
ZHANG Jinlian
Related Institution
Jiangxi University of Chinese Medicine
Jianchangbang Pharmaceutical Co. Ltd.
Third Grade Laboratory of Traditional Chinese Medicine(TCM) Preparations,National Administration of TCM,Shuguang Hospital Affiliated to Shanghai University of TCM
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
School of Chinese Materia Medica, Beijing University of Chinese Medicine