HOU Zi-yan, JIAO Fang, YANG Ye, et al. Effect of Chitosan Particles on Absorption of Berberine by Intestinal Perfusion[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(10): 11-14.
DOI:
HOU Zi-yan, JIAO Fang, YANG Ye, et al. Effect of Chitosan Particles on Absorption of Berberine by Intestinal Perfusion[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(10): 11-14.DOI: 10.13422/j.cnki.syfjx.2016100011.
Effect of Chitosan Particles on Absorption of Berberine by Intestinal Perfusion
Objective: To simulate particle system of traditional Chinese medicine decoction and to investigate effect of chitosan particles (CS-Ps) with different size on in situ intestinal absorption properties of berberine. Method: Chitosan particles with different particle size were prepared by high-voltage electrostatic spray method
its particle size and Zeta potential were evaluated by laser granularity analyzer.Intestinal absorption rate constant (Ka) and average apparent permeability (P < sub>app) of berberine were assayed by in situ intestinal perfusion model. Result: Particlesizes of CS-P1
CS-P2
and CS-P3 were (163.9±2.3)
(456.0±76.6)
(903.4±131.1) nm
Zeta potentials of them were (25.2±7.0)
(27.9±4.3)
(28.4±5.7)mV
respectively.There was no significant difference of surfacepotential value between different groups.Compared with the blank group
particlesize of CS-P1 and CS-P2 could promote intestinal absorption of berberine significantly (P < 0.05);however
CS-P3 group had no significant effect. Conclusion: Chitosan particles can promote intestinal absorption of berberine
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