ZHOU Chang-ni, FENG Qing-yun, XU Ru-bing, et al. Optimization of Prescription of Compound Gehuang Microporous Osmotic Pump Tablets by Central Composite Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(10): 20-24.
DOI:
ZHOU Chang-ni, FENG Qing-yun, XU Ru-bing, et al. Optimization of Prescription of Compound Gehuang Microporous Osmotic Pump Tablets by Central Composite Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(10): 20-24. DOI: 10.13422/j.cnki.syfjx.2016100020.
Optimization of Prescription of Compound Gehuang Microporous Osmotic Pump Tablets by Central Composite Design-response Surface Methodology
Objective: To optimize composition of compound Gehuang microporous osmotic pump tablets for providing a research model of microporous osmotic pump tablets of Chinese medicine effective components. Method: The content of total alkaloids in Coptidis Rhizoma was determined by ultraviolet spectrophotometry at 346 nm.Taking accumulative release rate of total alkaloids in Coptidis Rhizoma as index
based on single factor tests
central composite design-response surface methodology was adopted to optimize prescription with polyoxyethylene content and polyethylene glycol 400 content and coating weight as factors. Result: The best prescription were:Coptidis Rhizoma extract of 75 mg
Puerariae Lobatae Radix extract of 75 mg
NaCl of 72 mg
polyoxyethylene of 78 mg
microcrystalline cellulose of 15 mg
sodium dodecyl sulfate of 9 mg.In coating solution
concentrations of cellulose acetate
polyethylene glycol and dibutyl phthalate were 30
82
9 g·L-1
coating weight was 8.2%.Accumulative release rate in 12 h of total alkaloids was 81.9%. Conclusion: Release profile of compound Gehuang microporous osmotic pump tablets meets requirements
its zero order equation fitting degree reaches 0.990 9.This optimized preparation processes is stable and reasonable.
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Related Author
LING Xiao
HU Yuan-li
CHEN Fei-long
TAN Xiao-mei
Shuang CHENG
Xiang-yun CHEN
Ling-ling PAN
Yuan-yuan MA
Related Institution
Jiangxi University of Traditional Chinese Medicine
Ethnic Medicine School, Chengdu University of Traditional Chinese Medicine
Tibetan Medical College, Qinghai University
Drug Research Center for Nephropathy,Guangzhou Consun Pharmaceutical Co.Ltd
Key Laboratory of New Drug Delivery System of Chinese Meteria Medica,Jiangsu Provincial Academy of Chinese Medicine, Key Laboratory of Scientific Preparation for Clinical Effective Prescription of State Administration of Traditional Chinese Medicine