Objective: To study the best origin processing method of Lonicera Japonica Flos from different harvest time. Method: The samples of different harvest time and different processing methods were determined and compared with comprehensive scores and fingerprints of chlorogenic acid and luteoloside contents as the indicators. Result: The samples harvested from the third green period and the first white period had highest comprehensive score by gradient drying method. The samples harvested from second white period obtained the highest comprehensive score by direct drying method. The similarity of samples obtained by gradient drying method from the third green period and the first white period as well as the samples obtained by direct drying method from second white period was greater than 0.9 in fingerprints

with no significant differences in similarity and main characteristic peak area. Conclusion: The best origin processing method for the samples harvested from the third green period and the first white period was gradient drying method

and the best origin processing for the samples from second white period was direct drying method. There was no significant difference in quality of Lonicera Japonica Flos harvested from the above periods by the best processing methods.