FENG Shuang, BAO Hai-ying, CHI Meng-yi, et al. Pharmacokinetic and Tissue Distribution of 3-Keto-dehydrosulfurenic from in Rats[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(10): 84-87.
DOI:
FENG Shuang, BAO Hai-ying, CHI Meng-yi, et al. Pharmacokinetic and Tissue Distribution of 3-Keto-dehydrosulfurenic from in Rats[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(10): 84-87. DOI: 10.13422/j.cnki.syfjx.2016100084.
Pharmacokinetic and Tissue Distribution of 3-Keto-dehydrosulfurenic from in Rats
Objective: To investigate pharmacokinetics and tissue distribution of 3-keto- dehydrosulfurenic (3-keto-DSA) from Fomes officinalis in rats. Method: After oral administration of 12.5 mg·kg-1 and intravenous administration of 5 mg·kg-1to rats
blood concentration at different time point of 3-keto-DSA were determined by HPLC
parameters and bioavailability were calculated by 3P97 software.Tissue distribution of 3-keto-DSA in rats was studied after oral administration with dose of 25 mg·kg-1. Result: Two compartment model was fitted to 3-keto-DSA
its main pharmacokinetic parameters of 3-keto-DSA were as follows:t1/2ka of 0.381 h
t1/2α of 0.415 h
t1/2β of 3.852 h
tmax of 0.690 h
Cmax of 0.059 mg·L-1
F of 32.84%.The 3-keto-DSA was rapidly
extensively distributed to various rat tissues after oral administration of 25 mg·kg-1
time to reach maximum tissues concentration was about 30 min and it almost eliminated after 3 h.The concentration of 3-keto-DSA in each tissues was in the order of liver > spleen > heart > kidney. Conclusion: After oral administration
3-keto-DSA can be absorbed rapidly and distributed widely in blood and tissues
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Related Institution
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