Objective: To discuss clinical effect and safety of Xuanfei Jiedu granules in treating allergic rhinitis (AR

lung heat type). Method: Two hundred and twenty-two patients with AR were randomly divided into control group (102 cases) and observation group (120 cases) by random number table. Patients in control group orally took budesonide aerosol inhalation for 2-4 times

200-1 600 μg/day. Patients in observation group took Xuanfei Jiedu granules

10 g/time

2 times/day. Courses of treatment lasted for 7 days. Before and after treatment

scores of nasal obstruction

rhinocnesmus

sternutation and rhinorrhoea were evaluated by visual analogue scale (VAS)

and time of relief for the main symptoms (score≤3) and elapsed time (score=0) were recorded. Patients' qualities of live were evaluated by rhinoconjunctivitis quality of life questionnaire (RQLQ). And adverse reactions were recorded. Result: VAS scores

such as nasal obstruction

rhinocnesmus

sternutation and rhinorrhoea

obviously decreased after treatment (P < 0.01)

and scores of rhinocnesmus and sternutation decreased in observation group were lower than those in control group (P < 0.01)

with no statistically significant difference in scores of nasal obstruction and rhinorrhoea and time of relief of the four symptoms between the two groups. Elapsed time of nasal obstruction

rhinocnesmus and sternutation in observation group were shorter than those in control group (P < 0.05

P < 0.01)

with no statistical significant difference in elapsed time of rhinorrhoea. After treatment

scores of motion

sleep

no-rhinitis symptoms

relevant behaviors

sniffle

ocular symptoms

emotion and total scores in both groups decreased (P < 0.01). And scores of motion

sniffle

ocular symptoms and total scores in observation group were lower than those in control group (P < 0.05

P < 0.01). During the treatment

there was no serious adverse reaction in both groups. Conclusion: Compared with budesonide aerosol inhalation

Xuanfei Jiedu granules is better in controlling onset of symptom

improving patients' qualities of live and safer in the treatment of AR (lung heat type)

and so worth further studies.