Clinical Observation of Bazhen Decoction Combined with Tongqiao Huoxue Decoction in Treatment for Postoperative Brain Tumor with Qi-deficiency and Blood-stasis Syndrome

LIAO Xue-jian; SONG Zhi-fu; PANG Guo-yin; REN Li; XIA Xiang-guo

doi:10.13422/j.cnki.syfjx.2016100175

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Clinical Observation of Bazhen Decoction Combined with Tongqiao Huoxue Decoction in Treatment for Postoperative Brain Tumor with Qi-deficiency and Blood-stasis Syndrome

更新时间：2024-01-04

- Clinical Observation of Bazhen Decoction Combined with Tongqiao Huoxue Decoction in Treatment for Postoperative Brain Tumor with Qi-deficiency and Blood-stasis Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 10, Pages: 175-179(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016100175
  CLC： R739.41
- Published：2016
- 稿件说明：
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LIAO Xue-jian, SONG Zhi-fu, PANG Guo-yin, et al. Clinical Observation of Bazhen Decoction Combined with Tongqiao Huoxue Decoction in Treatment for Postoperative Brain Tumor with Qi-deficiency and Blood-stasis Syndrome[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(10): 175-179.
DOI：

LIAO Xue-jian, SONG Zhi-fu, PANG Guo-yin, et al. Clinical Observation of Bazhen Decoction Combined with Tongqiao Huoxue Decoction in Treatment for Postoperative Brain Tumor with Qi-deficiency and Blood-stasis Syndrome[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(10): 175-179. DOI： 10.13422/j.cnki.syfjx.2016100175.

摘要

目的: 观察八珍汤联合通窍活血汤加减辅助治疗脑肿瘤术后气虚血瘀证神经功能恢复的疗效以及对血清总超氧化物歧化酶(SOD)

过氧化氢酶(CAT)和还原型谷胱甘肽(GSH)的影响。方法: 选择脑肿瘤手术患者共110例

均参照数字表法随机分为治疗组和对照组各55例;两组患者在术后第1天开始均给予常规抗感染、对症治疗以及神经营养支持疗法;对照组从术后第1天开始给予盐酸纳美芬注射液治疗

8 μg·kg-1

1次/d

静脉滴注。治疗组在对照组用药的基础上给予八珍汤联合通窍活血汤加减辅助治疗

100 mL·d-1

于术后第1天开始经鼻饲管滴入;两组患者均给予2周治疗。比较两组中医临床症状

Barthel指数评分

简易精神状态量表(MMSE)和蒙特利尔认知评估量表(MoCA)评分;检测两组血清SOD

CAT和GSH含量。结果: 术后2周

治疗组中医症状各指标评分均明显低于对照组(P < 0.01);术后2周和4周

治疗组Barthel指数评分均分别高于对照组(P < 0.01);术后2周和4周

治疗组MMSE和MoCA评分均明显高于同时点对照组(P < 0.01);术后2周治疗组血清SOD

CAT和GSH水平均高于对照组

比较差异有统计学意义(P < 0.01)。结论: 八珍汤联合通窍活血汤加减辅助治疗脑肿瘤术后气虚血瘀证可明显改善患者临床症状

提高Barthel指数

MMSE和MoCA评分

上调氧化应激指标SOD

CAT和GSH水平。

Abstract

Objective: To observe the curative effect of Bazhen decoction combined with Tongqiao Huoxue decoction in adjuvant treatment for postoperative brain tumor with Qi-deficiency and blood-stasis syndrome and the influences on serum total superoxide dismutase (SOD)

catalase (CAT) and reduced glutathione (GSH). Method: One hundred and ten patients of postoperative brain tumor treated in department of neurosurgery of our hospital were selected and randomly divided into control group and treatment group (fifty-five cases in each group). Patients of two groups were given routine therapy of anti-infection

symptomatic treatment and nerve nutrition support. Patients of control group were treated with namefene hydrochloride injection by intravenous drip since the first day after operation (8 μg·kg-1

qd). In addition to the therapy of control group

patients of treatment group were treated with Bazhen decoction combined with Tongqiao Huoxue decoction through drip nasogastric tube since the first day after operation

100 mL·d-1. Patients of both groups were treated for two weeks. Syndromes of traditional Chinese medicine(TCM)

Barthel scores

mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) in both groups were compared. Levels of serum SOD

CAT and GSH were detected in both groups. Result: In the 2nd week after operation

index scores of TCM symptoms in treatment group were obviously lower than those of control group (P < 0.01). In the 2nd and 4th weeks after operation

Barthel scores in treatment group were evidently higher than those of control group (P < 0.01). In the 2nd and 4th weeks after operation

scores of MMSE and MoCA in treatment group were evidently higher than those of control group at the same time points (P < 0.01). In the 2nd week after operation

serum levels of SOD

CAT and GSH in treatment group were remarkably higher than those in control group

with statistical differences (P < 0.01). Conclusion: Bazhen decoction combined with Tongqiao Huoxue decoction in adjuvant treatment for postoperative brain tumor with Qi-deficiency and blood-stasis syndrome could improve clinical symptoms

increase Barthel indexes

and MMSE and MoCA scores

and up-regulate oxidative stress indexes of SOD

CAT and GSH.

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