Antidepressant Mechanism and Application of Glycyrrhizma Radix et Rhizoma

ZONG Yang; HE Shu-fen; SUN Bing-ting; ZHANG Qian; JU Wen-zheng

doi:10.13422/j.cnki.syfjx.2016100194

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Antidepressant Mechanism and Application of Glycyrrhizma Radix et Rhizoma

更新时间：2024-01-04

- Antidepressant Mechanism and Application of Glycyrrhizma Radix et Rhizoma
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 10, Pages: 194-198(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016100194
  CLC： R285.5
- Published：2016
- 稿件说明：
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ZONG Yang, HE Shu-fen, SUN Bing-ting, et al. Antidepressant Mechanism and Application of Glycyrrhizma Radix et Rhizoma[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(10): 194-198.
DOI：

ZONG Yang, HE Shu-fen, SUN Bing-ting, et al. Antidepressant Mechanism and Application of Glycyrrhizma Radix et Rhizoma[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(10): 194-198. DOI： 10.13422/j.cnki.syfjx.2016100194.

摘要

探讨甘草治疗抑郁症的特点。查阅近年来关于中药甘草治疗抑郁症的相关文献

从甘草抗抑郁活性成分及其在中药复方中的应用等方面分析甘草治疗抑郁症的特点。甘草治疗抑郁症应用广泛

在改善动物行为学和生化指标上都有良好的疗效

其机制主要涉及调节脑内单胺类神经递质及其受体、改善下丘脑-垂体-肾上腺(HPA)轴功能、抗自由基、抗炎等作用。甘草治疗抑郁症具有疗效稳定、作用持久、不良反应小等特点

为临床筛选其抗抑郁中药活性成分以及处方配伍提供思路和借鉴。

Abstract

To explore the characteristics of Glycyrrhizma Radix et Rhizoma in treatment of the depression. Related literature about Chinese medicine Glycyrrhizma Radix et Rhizoma for treatment of the depression in recent years was looked up to analyze the characteristics of Glycyrrhizma Radix et Rhizoma for the treatment of depression from the perspectives of antidepressant active ingredients and its application in Chinese medicine compounds. Glycyrrhizma Radix et Rhizoma has been widely used in the treatment of depression

with good curative effect in improving animal behavior and biochemical indicators

and the mechanism is mainly associated with regulating monoamine neurotransmitter and receptors in the brain

improving the hypothalamus-pituitary-adrenal (HPA) axis function

anti-free radicals

and anti-inflammatory effects. Glycyrrhizma Radix et Rhizoma treatment for depression has stable efficacy

long-lasting effect and less adverse reactions

providing for ideas and references for clinical screening of the antidepressant Chinese medicine active ingredients and prescription compatibility.

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Related Institution

Hebei University of Chinese Medicine

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College of Traditional Chinese Medicine（TCM）， Hubei University of Chinese Medicine

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