RONG Yue-ying, FENG Su-xiang, WU Chun-wei, et al. Research Progress of Pharmacokinetics and Metabolism of Chemical Compositions in Rhei Radix et Rhizoma[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(10): 199-204.
DOI:
RONG Yue-ying, FENG Su-xiang, WU Chun-wei, et al. Research Progress of Pharmacokinetics and Metabolism of Chemical Compositions in Rhei Radix et Rhizoma[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(10): 199-204.DOI: 10.13422/j.cnki.syfjx.2016100199.
Research Progress of Pharmacokinetics and Metabolism of Chemical Compositions in Rhei Radix et Rhizoma
Rhei Radix et Rhizoma is a widely used crude herb.Currently
pharmacokinetic and metabolism studies of chemical components in Rhei Radix et Rhizoma was focused on free anthraquinones.This paper focused on current reports of pharmacokinetic and metabolism studies of Rhei Radix et Rhizoma
and illuminated its characteristics of pharmacokinetic and metabolism.Based on related references
anthraquinones were absorbed rapidly
but eliminated slowly.However
its absorption and elimination was easily affected by formula compatibility and body status.According to reports on in vivo and in vitro metabolism of Rhei Radix et Rhizoma
its major metabolic pathway was glucuronidation
sulfation
methylation
etc.Besides
its metabolites was mainly derived from anthraquinones.
Change Law in Material Basis of Rhei Radix et Rhizoma During Nine-time Repeating Steaming and Sun-drying Processing Based on Characteristic Chromatogram and Chemometrics
Comparison of Pharmacokinetics and Tissue Distribution of Free Anthraquinones and Gallic Acid in Mice with Ulcerative Colitis Before and After Processing of Rhei Radix et Rhizoma Carbonisata
Effect of Rhei Radix et Rhizoma Before and After Steaming with Wine on Intestinal Flora and Immune Environment in Constipation Model Mice
Progress of Rhei Radix et Rhizoma and Its Combination in Treatment of Cerebral Hemorrhage: A Review
Metabolic Analysis of Tongfengding Capsules in vivo Based on Sequential Metabolism
Related Author
AO Xuan
LIU Taotao
YU Miao
WANG Lan
YIN Xiaojie
ZUO Jingyu
LI Li
SUN Jing
Related Institution
Chongqing Tongjunge Pharmaceutical Factory Co. Ltd. of Taiji Group
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
School of Life Sciences,Beijing University of Chinese Medicine
Hanlin College,Nanjing University of Chinese Medicine
Shaanxi Engineering Technology Research Center of Chinese Herbal Pieces,Shaanxi Qinling Application Development and Engineering Research Center of Chinese Herbal Medicine,Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine(TCM) for TCM Compatibility, Shaanxi University of Chinese Medicine,Xi′an