Correlation Between Agaropiric Acid and Extract Contents in Artificial Aquilariae Lignum Resinatum

ZHOU Xin; FAN Yun-fei; LEI Zhi-dong; PAN Qing-ling; ZHONG Zhao-jian; LIU Dai-lin; ZHANG Wei-min; GAO Xiao-xia

doi:10.13422/j.cnki.syfjx.2016110055

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Correlation Between Agaropiric Acid and Extract Contents in Artificial Aquilariae Lignum Resinatum

更新时间：2024-01-04

- Correlation Between Agaropiric Acid and Extract Contents in Artificial Aquilariae Lignum Resinatum
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 11, Pages: 55-59(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016110055
  CLC： R284.1
- Published：2016
- 稿件说明：
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ZHOU Xin, FAN Yun-fei, LEI Zhi-dong, et al. Correlation Between Agaropiric Acid and Extract Contents in Artificial Aquilariae Lignum Resinatum[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(11): 55-59.
DOI：

ZHOU Xin, FAN Yun-fei, LEI Zhi-dong, et al. Correlation Between Agaropiric Acid and Extract Contents in Artificial Aquilariae Lignum Resinatum[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(11): 55-59. DOI： 10.13422/j.cnki.syfjx.2016110055.

摘要

目的: 建立高效液相色谱法测定人工沉香中白木香酸含量的方法

研究其白木香酸与浸出物含量之间的相关性。方法: 按2015年版《中国药典》一部进行醇溶性浸出物的含量测定;采用CNW Athena C18-WP色谱柱(4.6 mm×250 mm

5 μm)

流动相乙腈-0.1%磷酸水溶液(40:60)

流速1.0 mL·min-1

检测波长217 nm

柱温35℃。结果: 白木香酸线性范围0.24~24 mg·L-1(r=0.999 7)

精密度(RSD)0.4%

24 h内稳定性RSD 0.9%

白木香酸的平均质量分数为27.86 μg·g-1

平均回收率96.4%

RSD 2.8%。结论: 高效液相法可准确测定人工沉香中白木香酸的含量

所选结香方式中综合法的白木香酸平均含量最高

且白木香酸的含量随着浸出物含量的增加而增加

结合白木香酸与浸出物含量的相关性

可为人工沉香的质量评价提供依据。

Abstract

Objective: To establish a HPLC method for the determination of agaropiric acid in artificial agarwood and study the correlation between agaropiric acid and extract contents. Method: The content of ethanol-soluble extract was determined according to those correlative standards of Aquilariae Lignum Resinatum in Chinese Pharmacopoeia (2015 Version);HPLC was done on CNW Athena C18-WP column (4.6 mm×250 mm

5 μm)

with acetonitrile-0.1% phosphoric acid solution (40: 60) as the mobile phase at a flow rate of 1.0 mL·min-1. The detection wavelength was set at 217 nm and the column temperature was 35℃. Result: The linear range of agaropiric acid was 0.24-24 mg·L-1 (r=0.999 7). RSD was 0.4% for precision degree and 0.9% for stability within 24 h

the average mass fraction of agaropiric acid was 27.86 μg·g-1

and its average recovery rate was 96.4% with RSD of 2.8%. Conclusion: This HPLC method is accurate for determination of agaropiric acid content. The average content of agaropiric acid was highest in comprehensive way

and the content of agaropiric acid is increased with the increase of ethanol-soluble extract content. This correlation can provide the relativity of contents between the ethanol-soluble extract and agaropiric acid

and provide a reference for quality evaluation of artificial agarwood.

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