Objective: To observe the effects of Shiquan Dabu Tang combined with Wuwei Xiaodu Yin on immune function and living quality in postoperative Qi and blood deficiency patients with esophagus cancer. Method: Ninety eligible patients were selected in this study and randomly divided into control group (44 cases) and treatment group (46 cases). Patients in control group received enteral nutrition supporting therapy on postoperative day 2 to day 9. Patients in treatment group were treated with Shiquan Dabu Tang combined with Wuwei Xiaodu Yin based on the treatment in control group. Symptom scores of traditional Chinese medicine (TCM) were compared between two groups. Levels of serum CD4+

CD8+

IgA

IgG and IgM were detected in serum of two groups. Quality of Life Questionary-Core 30 (EORTC QLQ-C30) V3.0 scores and Esophageal Cancer Supplementary Schema Table (QLQ-OES18) scores were compared between two groups. Result: The TCM symptom scores in treatment group were significantly lower than those in control group on postoperative day 10(P < 0.01)

CD4+

CD4+/CD8+

IgA

IgG and IgM levels in treatment group were significantly higher than those in control group on postoperative day 10

while CD8+ level was significantly lower than that in control group(P < 0.01)

scores of functional area indexes in treatment group were significantly higher than those of control group

while scores of symptom area indexes in treatment group were significantly lower than those of control group(P < 0.01)

on postoperative day 10

scores of EORTC QLQ-OES18 in treatment group were significantly lower than those of control group with statistical differences (P < 0.01). Conclusion: Based on enteral nutrition supporting therapy

Shiquan Dabu Tang combined with Wuwei Xiaodu Yin in treatment of postoperative esophagus cancer with deficiency of Qi and blood could improve TCM symptoms and quality of life

and increase immune function.