End Point Judgment of Blending Process of Zhengtian Pills by Near Infrared Spectroscopy

CHEN Hong-ying; LI Qiong-ya; CHEN Jia-le; LUAN Lian-jun; DAI Yao-xia

doi:10.13422/j.cnki.syfjx.2016120013

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End Point Judgment of Blending Process of Zhengtian Pills by Near Infrared Spectroscopy

更新时间：2024-01-04

- End Point Judgment of Blending Process of Zhengtian Pills by Near Infrared Spectroscopy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 12, Pages: 13-16(2016)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2016120013
  CLC： O657.3;R286.0
- Published：2016
- 稿件说明：
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CHEN Hong-ying, LI Qiong-ya, CHEN Jia-le, et al. End Point Judgment of Blending Process of Zhengtian Pills by Near Infrared Spectroscopy[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(12): 13-16.
DOI：

CHEN Hong-ying, LI Qiong-ya, CHEN Jia-le, et al. End Point Judgment of Blending Process of Zhengtian Pills by Near Infrared Spectroscopy[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(12): 13-16. DOI： 10.13422/j.cnki.syfjx.2016120013.

摘要

目的:利用近红外光谱(near-infrared spectroscopy

NIR)技术分析正天丸的混合过程

建立一种快速判断混合终点的方法

以提高混合过程的均匀度和混合效率。方法:采用在线取样采集正天丸混合过程中粉末的NIR

计算不同时间点混合均匀度

利用主成分分析(principal component analysis

PCA)结合马氏距离判断粉末混合终点。采用HPLC测定不同混合时间点芍药苷含量以验证定性判断结果

检测波长235 nm

流动相0.05%磷酸-乙腈梯度洗脱。结果:随着混合时间的延长

粉末混合均匀度增大

20 min后达97%以上;PCA-马氏距离判断结果显示20 min后

到校正光谱的马氏距离基本保持不变(<1.0)

提示混合达到均匀状态

定量验证结果显示20 min后芍药苷含量的RSD趋于稳定。结论:近红外光谱技术可用于判定正天丸的混合过程终点

为其他大品种制剂的研究提供了参考。

Abstract

Objective: A rapid method was established to judge the end point of blending process of Zhengtian pills by near-infrared spectroscopy

which was in order to improve blending efficiency of this preparation. Method: Near-infrared spectroscopy of blending samples were collected

then blending uniformity was calculated at different time. Principal component analysis (PCA) combined with Mahalanobis distance was used to identify the end point of blending process. HPLC was employed to determine the content of paeoniflorin in order to verify judgment. Result: Blending uniformity of powders increased with blending time extended. After 20 min

blending uniformity reached more than 97%. PCA-Mahalanobis distance results showed that distance remained below 1.0 and kept unchanged basically

suggesting that blending process reached the end point. Quantitative validation results showed that RSD of paeoniflorin content tended to stable after 20 min. Conclusion: Near-infrared spectroscopy technology can be used to determine the end point of blending process of Zhengtian pills.

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