Optimization of Formulation of Platycodonis Radix Effervescent Tablets by Central Composite Design-response Surface Methodology

WANG Shuang-shuang; LIU Rui; HE Xin

doi:10.13422/j.cnki.syfjx.2016120023

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Optimization of Formulation of Platycodonis Radix Effervescent Tablets by Central Composite Design-response Surface Methodology

更新时间：2024-01-04

- Optimization of Formulation of Platycodonis Radix Effervescent Tablets by Central Composite Design-response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 12, Pages: 23-27(2016)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2016120023
  CLC： R283.6
- Published：2016
- 稿件说明：
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WANG Shuang-shuang, LIU Rui, HE Xin. Optimization of Formulation of Platycodonis Radix Effervescent Tablets by Central Composite Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(12): 23-27.
DOI：

WANG Shuang-shuang, LIU Rui, HE Xin. Optimization of Formulation of Platycodonis Radix Effervescent Tablets by Central Composite Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(12): 23-27. DOI： 10.13422/j.cnki.syfjx.2016120023.

摘要

目的:优选桔梗泡腾片的处方

为桔梗汤的临床应用提供参考。方法:在单因素试验基础上

选取对桔梗泡腾片处方影响较大的甘露醇用量、泡腾剂用量及泡腾剂酸碱比(酒石酸-碳酸氢钠)为自变量

崩解时间和pH为因变量

根据星点设计原理进行试验

并利用多元线性回归、二项式方程和三项式方程拟合因变量与自变量之间的数学模型

经效应面法优选桔梗泡腾片的处方。结果:桔梗泡腾片的最优处方为浸膏粉37.58%

酒石酸16.70%

碳酸氢钠20.88%

甘露醇19.53%

聚乙二醇-6000 2.29%

阿司帕坦2.50%

硬脂酸镁0.52%

泡腾剂酸碱比1:1.25

甘露醇、泡腾剂用量分别为浸膏粉用量的52%

100%。崩解时间224 s

pH 5.32。结论:桔梗泡腾片崩解迅速、口感良好、服用方便

星点设计-效应面法建立的模型预测性良好

可用于该制剂处方的优化。

Abstract

Objective: To optimize formulation of Platycodonis Radix effervescent tablets. Method: On the basis of single-factor tests

taking effervescent acid-base ratio

the amount of mannitol and effervescent as independent variables

disintegration time and pH as dependent variables. Experiments were based on central composite design

mathematical models were simulated by multiple-linear equation

second-order polynomial equation and triple-order polynomial equation. Optimal formulation of Platycodonis Radix effervescent tablets was predicted by response surface methodology. Result: Optimum formula was as follows:acid-base ratio of 1:1.25 (tartaric acid-NaHCO3)

mannitol amount of 52% and effervescent amount of 100% to extract powder. Under these conditions

disintegration time of Platycodonis Radix effervescent tablets was 224 s and pH was 5.32. Conclusion: Platycodonis Radix effervescent tablets can be obtained with good taste

rapidly disintegration and convenience in using. Central composite design-response surface methodology is successfully used to optimize formulation of this preparation with good predictability.

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