Preparation and Solution Conformation of Acetylated  Polysaccharide

ZHANG Yan; CHEN Guan; ZHAO Zhen-yu; ZHANG Gui-xian; FU Yu; LIU Qing-huan; TAO Zun-wei

doi:10.13422/j.cnki.syfjx.2016120079

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Preparation and Solution Conformation of Acetylated Polysaccharide

更新时间：2024-01-04

- Preparation and Solution Conformation of Acetylated Polysaccharide
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 12, Pages: 79-83(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016120079
  CLC： R284.1
- Published：2016
- 稿件说明：
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ZHANG Yan, CHEN Guan, ZHAO Zhen-yu, et al. Preparation and Solution Conformation of Acetylated Polysaccharide[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(12): 79-83.
DOI：

ZHANG Yan, CHEN Guan, ZHAO Zhen-yu, et al. Preparation and Solution Conformation of Acetylated Polysaccharide[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(12): 79-83. DOI： 10.13422/j.cnki.syfjx.2016120079.

摘要

目的:制备乙酰化苦豆子多糖

并对修饰后的乙酰化苦豆子多糖溶液的构象特征进行研究。方法:对苦豆子多糖进行乙酰化修饰

采用取代度测定、红外光谱分析手段对修饰结果进行验证

采用碘-碘化钾反应和刚果红试验研究乙酰化苦豆子多糖的构象特征

采用圆二色谱法(CD)对不同因素影响下乙酰化苦豆子多糖的溶液行为进行研究。结果:乙酰化苦豆子多糖修饰成功

取代度为0.84

其溶液行为显示乙酰化苦豆子多糖具有多股螺旋结构以及较长的侧链和较多的分支

并且溶液构象受浓度、温度以及添加金属离子的影响而变化。结论:成功修饰获得乙酰化苦豆子多糖

并对其溶液构象进行了全面研究

为其进一步研究提供了参考。

Abstract

Objective: To prepare the acetylated Sophora alopecuroides polysaccharide (AC-SAP)

and study the conformation characteristics of the modified acetylated S. alopecuroides polysaccharide solution. Method: S. alopecuroides polysaccharide was modified by acetylization

and the modification results were verified by means of the substitution determination method and infrared spectroscopy analysis. The conformation characteristics of acetylated S. alopecuroides polysaccharide was studied by I2-KI reaction and Congo red test. Solution behavior of acetylated S. alopecuroides polysaccharide under different conditions were studied by circular dichroism (CD) spectrum. Result: Acetylated S. alopecuroides polysaccharide was successfully modified and its substitution degree was 0.84. Its solution behavior indicated multiple helixes structure with long side chains and many branches in solution. In addition

its solution conformation could be affected by the concentration

temperature and metalions. Conclusion: Comprehensive research on the solution conformation of successfully modified acetylated S. alopecuroides polysaccharide can provide reference for further research.

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Related Author

ZHAO Yong-an

TAO Zun-wei

ZHAO Yong-an1

CHEN Guan2

TAO Zun-wei2

Related Institution

Tianjin Medical University

Tianjin Institute of Medical and Pharmaceutical Sciences

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