Objective: To investigate effects of salvianolic acids compatible with borneol at different concentration on absorption rate constant (Ka) and apparent absorption coefficient (Papp) of salvianolic acid B

lithospermic acid and rosmarinic acid in rat small intestine. Method: An in situ intestinal perfusion model was employed to investigate absorption of salvianolic acids in rat small intestine. HPLC was used to determine contents of salvianolic acid B

lithospermic acid and rosmarinic acid

mobile phase was 1% glacial acetic acid water solution-1% glacial acetic acid methanol solution

detection wavelength was 286 nm

flow rate was 0.8 mL·min-1. Result: Compatibility of salvianolic acids with different concentration of borneol

both Ka and Papp were increased

enhancing effect of borneol with the concentration of 100 mg·L-1 was optimum. Ka of salvianolic acid B

lithospermic acid and rosmarinic acid in borneol with the concentration of 100 mg·L-1 was 2.31

2.33

3.38 times as long as the blank group. Conclusion: After compatibility of salvianolic acids with different concentrations of borneol

there is significant promoting effect of salvianolic acid B

lithospermic acid and rosmarinic acid in absorption of all segments of intestine. The capacity of enhancing effect is influenced by the concentration of borneol. When the concentration of borneol increases

the enhancing effect of salvianolic acids in intestinal absorption increases

but it significantly decreases after the concentration of borneol increases to some degree.