Objective: To evaluate the clinical efficacy of Wendan Tang on urinary microalbumin/creatinine ratio in patients with resistant hypertension

and clarify its protective effect on renal function. Method: The 90 patients with resistant hypertension from chronic diseases outpatient and inpatient of our hospital during September 2012-September 2014 were randomly divided into treatment group and control group. Blood pressure

traditional Chinese medicine(TCM) syndromes

and biochemical indicators were recorded before and after treatment for both groups. Urinary microalbumin/creatinine ratio levels were detected and analyzed before and after treatment. Result: In respect of blood pressure

the systolic blood pressure and diastolic blood pressure in treatment group were lower than those in the control group

with statistical difference (P<0.05). In respect of TCM syndromes

the results showed that was a total effective rate of 84.1% in the treatment group (44 cases)

while in the control group the total effective rate was 58.1%

with significant differences between two groups (P<0.05). In respect of biochemical indicators

urinary microalbumin/creatinine of the biochemical indicators was significantly decreased in the treatment group (P<0.05). After treatment

renal dysfunction was present in treatment group significantly lower than the control group (P<0.05). Conclusion: Wendan Tang has significant effects in reducing the blood pressure for resistant hypertension patients

improving clinical symptoms

and reducing toxins in the blood and urinary microalbumin/creatinine

with a protective effect on renal function

so it is worthy of clinical application.