Objective: To observe the treatment efficacy of Qingre Jiedu Huoxue Tongluo formula combined with Fufang Huangbai liquid on the diabetic foot. Method: The 178 patients with diabetic foot from the Department of Endocrinology of the Third Affiliated Hospital of Qiqihar Medical University from April 2014 to May 2015 were randomly divided into the observation group (89 cases) and the control group (89 cases). In the observation group

patients were treated with Qingre Jiedu Huoxue Tongluo formula by orally taking and Fufang Huangbai liquid by topical application for three weeks

in the control group

patients were treated with topical Kangfuxin for three weeks. Then the changes of tumor necrosis factor (TNF)-α

vascular endothelial growth factor (VEGF) and interleukin (IL)-6 levels in serum

improvement of clinical symptoms and the changes of blood and nerve indexes were observed in both groups

the correlation between the blood and nerve indexes and related cytokines was analyzed by the method of biological statistics. Result: There was statistically significant difference in therapeutic effect between two groups (P<0.01). There were statistically significant differences in the blood flow rate of dorsalis pedis artery and the conduction velocity of peroneal nerve between two groups (P<0.01). At the first

second and third weeks of treatment

there were statistically significant differences in TNF-α

IL-6 and VEGF levels in the serum between two groups (P<0.01). The blood flow velocity of dorsalis pedis artery was positively correlated with TNF-α and IL-6 levels

but was negatively correlated with VEGF level. The conduction velocity of peroneal nerve was positively correlated with VEGF level

but was negatively correlated with TNF-α and IL-6 levels. Conclusion: Qingre Jiedu Huoxue Tongluo formula combined with Fufang Huangbai liquid has a good therapeutic effect on diabetic foot

so it is worthy of clinical popularizing and application.