Objective: To investigate the efficacy of Tongnao Huoxin decoction in treatment of primary hypertension with syndrome of internal blockade of static blood and observe its effect on blood pressure variability and levels of homocysteine (HCY) and 25-hydroxyvitamin D [25(OH)D] in serum. Method: One hundred and ten patients were randomly divided into control group and treatment group (55 cases in each group) according to random number table in the study. Patients in control group were treated with amlodipine besylate tablets (5 mg/time

1 tablet/day) and enalapril maleate tablets (10 mg/time

1 table/day). Patients in treatment group were treated with Tongnao Huoxin decoction orally based on the treatment in control group (1 dose/day

bid). The treatment course was two months in both groups. Changes of hemorheology indexes and blood pressure variability indexes pre-post treatment were compared between two groups. Clinic effects of two groups after treatment were analyzed. Levels of Hcy and 25 (OH) D in serum of two groups were detected. Result: The whole blood high shear viscosity

middle shear viscosity

low shear viscosity and plasma viscosity in treatment group were significantly lower than those of control group after treatment (P<0.01). The total effective rate was 92.73% in treatment group

higher than 76.36% in control group (P<0.05). Standard deviation of diastolic blood pressure in 24 h (24 hDSD)

standard deviation of daytime diastolic blood pressure (dDSD)

standard deviation of daytime systolic blood pressure (dSSD)

and standard deviation of nighttime diastolic blood pressure (nDSD) in treatment group were significantly lower than those of control group after treatment (P<0.01). After treatment

the level of Hcy in serum of treatment group was significantly lower than that of control group

while 25 (OH) D level was significantly higher than that of control group

with statistically significant difference (P<0.01). Conclusion: Tongnao Huoxin decoction based on western medicine could significantly improve blood viscosity

blood pressure variability and raise clinical effects in treatment of primary hypertension with syndrome of internal blockade of static blood

and the mechanism may be associated with reducing the level of Hcy in serum and elevating 25 (OH) D level.