Optimization of Preparation Process of Huoxue Cataplasm by Central Composite Design-response Surface Methodology

ZHAO Li-jian; LIU Shan-xin; SU Ming; BI Jian-yun; WANG Ping; FENG Cheng

doi:10.13422/j.cnki.syfjx.2016130019

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Optimization of Preparation Process of Huoxue Cataplasm by Central Composite Design-response Surface Methodology

更新时间：2024-01-04

- Optimization of Preparation Process of Huoxue Cataplasm by Central Composite Design-response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 13, Pages: 19-22(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016130019
  CLC： R283.6
- Published：2016
- 稿件说明：
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ZHAO Li-jian, LIU Shan-xin, SU Ming, et al. Optimization of Preparation Process of Huoxue Cataplasm by Central Composite Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(13): 19-22.
DOI：

ZHAO Li-jian, LIU Shan-xin, SU Ming, et al. Optimization of Preparation Process of Huoxue Cataplasm by Central Composite Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(13): 19-22. DOI： 10.13422/j.cnki.syfjx.2016130019.

摘要

目的: 优选活血巴布膏的成型工艺

为制备符合临床需要的巴布膏奠定基础。方法: 以黏附性、外观均匀性、膜残留性、皮肤追随性、揭帖性与基质残留、涂展性等的综合评分为因变量

在单因素试验基础上

采用星点设计-效应面法考察聚丙烯酸钠-700

甘油

甘羟铝及聚维酮K-90用量对活血巴布膏成型工艺的影响。结果: 活血巴布膏基质最佳配比聚丙烯酸钠-700-聚乙烯醇-甘油-甘羟铝-聚维酮K-90-微粉硅胶-水-药膏为4.7:0.5:29.2:0.5:3:4:22.4:12.9。制备的活血巴布膏易于涂布、膏面光洁、色泽一致、禙衬平整无渗漏、皮肤追随性及初黏力良好、揭贴无痛感、无残留。结论: 优选的成型工艺科学合理、稳定可行

为活血巴布膏的开发提供参考。

Abstract

Objective: To optimize preparation process of Huoxue cataplasm. Method: Taking composite score of adhesion

appearance uniformity

film residue

skin compliance

spreadability and others as index

based on single factor tests

central composite design-response surface methodology was used to optimize preparation process with amounts of sodium polyacrylate-700

glycerin

aluminium glycinate and povidone K-90 as factors. Result: Optimum substrate composition was sodium polyacrylate-700/polyvinyl/glycerin/aluminium glycinate/povidone K-90/aerosil/water/ointment was 4.7:0.5:29.2:0.5:3:4:22.4:12.9.Cataplasm was coated easily with smooth cream surface

consistent color

good skin followability and no leakage. Conclusion: This preparation process is rational and suitable for production of Huoxue cataplasm.

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