Percolation Process of Gubi Zhitong Liquor by Comprehensive Scoring Method

LI Xi-xiang; LI Xing-yong; LIU Xiao-shuan; WANG Xue-mei; BAO Qiang

doi:10.13422/j.cnki.syfjx.2016130031

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Percolation Process of Gubi Zhitong Liquor by Comprehensive Scoring Method

更新时间：2024-01-04

- Percolation Process of Gubi Zhitong Liquor by Comprehensive Scoring Method
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 13, Pages: 31-33(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016130031
  CLC： R283.6
- Published：2016
- 稿件说明：
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LI Xi-xiang, LI Xing-yong, LIU Xiao-shuan, et al. Percolation Process of Gubi Zhitong Liquor by Comprehensive Scoring Method[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(13): 31-33.
DOI：

LI Xi-xiang, LI Xing-yong, LIU Xiao-shuan, et al. Percolation Process of Gubi Zhitong Liquor by Comprehensive Scoring Method[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(13): 31-33. DOI： 10.13422/j.cnki.syfjx.2016130031.

摘要

目的: 优选骨痹止痛液的渗漉工艺条件

为该制剂的工业化生产提供参考。方法: 以欧前胡素、阿魏酸、桂皮醛提取量和干浸膏得率的综合评分为指标

采用正交试验对影响渗漉工艺的药材粉碎粒度、浸泡时间、白酒用量和渗漉速度4个因素进行优选。采用HPLC测定欧前胡素、阿魏酸、桂皮醛含量

检测波长分别为254

320

290 nm

流动相依次为甲醇-水(60:40)

甲醇-1%冰乙酸水溶液(30:70)和甲醇-水(35:65)。结果: 骨痹止痛液最佳渗漉工艺为药材粉碎过50目筛

加10倍量白酒浸泡24 h

以2 mL·min-1的流速渗漉。欧前胡素、阿魏酸、桂皮醛提取量分别为69.888

171.840

123.845μg·g-1

干浸膏得率32.16%。结论: 优选的渗漉工艺简便稳定、重复性好

为骨痹止痛液的进一步开发与利用提供实验依据。

Abstract

Objective: To optimize percolation technology of Gubi Zhitong liquor and to provide a reference for industrial production of this preparation. Method: Taking composite score of extracting amounts of imperatorin

ferulic acid

cinnamaldehyde and dry extract yield as index

orthogonal test was adopted to optimize percolation technology with powder fineness

soaking time

percolation speed and liquor amount.HPLC was employed to determine contents of imperatorin

ferulic acid and cinnamaldehyde with detection wavelengths of 254

320

290 nm and mobile phases of methanol-water (60:40)

methanol-1% glacial acetic acid solution (30:70) and methanol-water (35:65). Result: Optimal percolation technology was as follows:powder fineness of 50 mesh

soaked 24 h with 10 times the amount of liquor

percolation speed of 2 mL·min-1.Under these conditions

extracting amounts of imperatorin

ferulic acid

cinnamaldehyde were 69.888

171.840

123.845 μg·g-1

dry extract yield was 32.16%. Conclusion: This optimized percolation process is simple and stable with good repeatability

it can provide a theoretical basis for further developing of Gubi Zhitong liquor.

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Related Institution

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