Objective: To investigate the effects of Qianyang Yuyin granules (QYYYG) on oxidative stress and inflammation factors in kidney of spontaneously hypertensive rats (SHRs). Method: SHRs were randomly divided into model group

QYYYG group

Benazepril group

and QYYYG+Benazepril group. The rats received QYYYG suspension (5 g·kg-1)

Benazepril suspension (1.67 mg·kg-1)

QYYYG suspension (5 g·kg-1)+Benazepril suspension (1.67 mg·kg-1) respectively by intragastric administration. WKY rats were used as normal group

and their renal tissues were collected after 8 weeks of same volume administration.The changes of blood pressure

trace albumin

and creatinine in rats were observed;local NADPH oxidase-4 (NOX4) levels

nuclear factor-κB (NF-κB) p65

interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) protein expression levels of kidney were detected by Western blot;the effects of QYYYG on the release of these indicators were observed. Result: Compared with the normal group

the model gorup showed significant increase in blood pressure

trace albumin

and creatinine in rats

and NOX4

NF-κB p65

IL-6

and TNF-α protein expression levels in kidney of SHRs(P < 0.01). QYYYG can inhibit the expression of NOX4

reduce the NF-κB p65

IL-6

and TNF-α protein expression levels in kidney of SHRs

meanwhile it can reduce blood pressure

trace ablumin

and creatintine(P < 0.01)

and the synergy effect was more obvious in case of combination of Qianyang Yuyin granules and Benazepril. Conclusion: QYYYG can improve the renal impairment of SHRs

and the mechanism may be associated with inhibiting oxidative stress and reducing the release of inflammation factors.