Objective: To investigate the clinical efficacy of Bailing Tiaogan decoction in treating infertilitas feminis of liver Qi stagnation type polycystic ovary syndrome (PCOS)

and observe its effects on levels of free fat acid (FFA)

C-reactive protein (CRP) and β-endorphin (β-EP) in serum. Method: One hundred and ten eligible patients were randomly divided into control group (55 cases) and observation group (55 cases) by random number table.Patients of control group were given with ethinylestradiol and cyproterone acetate tablets and clomiphene citrate capsules for ovulation induction. The patients in observation group were treated with Bailing Tiaogan decoction (1 dose/day

bid) by oral administration based on the observation of control group. The treatment course was four menstrual cycles for both groups. Scores of clinical symptoms

endometrial thickness

and ovarian volume were compared between two groups. Clinical pregnancy rate was recorded within six menstrual cycles (MCs) for both groups. The levels of FFA

CRP and β-EP in serum were detected pre-post treatment in two groups. Result: Traditional Chinese medicine (TCM) symptom scores in treatment group were lower than those in control group after treatment (P < 0.01). Within six MCs

the clinical pregnancy rate was 60% in observation group

significantly higher than 36.36%in control group (P < 0.05). The endometrial thickness in treatment group was significantly higher than that in control group after treatment

while the ovarian volume was significantly lower than that in control group (P < 0.01). The levels of FFA and CRP in serum of observation group were significantly lower than those of control group after treatment

while β-EP level was significantly higher than that of control group

with statistically significant differences (P < 0.01). Conclusion: On the basis of control group treatment

Bailing Tiaogan decoction could significantly improve clinical symptoms

increase endometrial thickness

decrease ovarian volume

and increase clinical pregnancy rate in treating infertilitas feminis of liver Qi stagnation type PCOS

and the action mechanism may be related with reducing the FFA and CRP levels and increasing β-EP level in serum.