Objective: To systematically review the effectiveness and safety of Xuefu Zhuyu Tang combined with western medicine in the treatment of diabetic peripheral neuropathy (DPN). Method: Such databases as Pubmed

Embase

Cochrane library

CNKI

CBM

VIP database and Wanfang data were searched to collect randomized clinical trials on the effectiveness and safety of Xuefu Zhuyu Tang combined with western medicine in the treatment of DPN. According to the inclusion and exclusion criteria

literatures were screened

data was extracted

and the methodological quality of included studies was also assessed. Then

a Meta-analysis was performed using RevMan 5.3 software. Result: The 23 RCT were included eventually

involving a total of 1 933 cases treated with Xuefu Zhuyu Tang combined with western medicine in the treatment of DPN. The analysis shows that the effectiveness and safety of Xuefu Zhuyu Tang combined with western medicine in the treatment of DPN were superior to those of pure western medicine. The treatment group showed a total effective rate of[RR=1.27

95%CI(1.21

1.33)

P < 0.001]

median nerve motor merve conduction velocity(MNCV) of[MD=5.28

95%CI(3.16

7.41)

P < 0.001]

median nerve sensory nerve conduction veldity(SNCV) of[MD=3.66

95%CI(1.78

5.55)

P=0.001]

common peroneal nerve MNCV of[MD=6.97

95%CI(4.59

9.35)

P < 0.001]

common peroneal nerve SNCV of[MD=3.68

95%CI(2.41

4.95)

P < 0.001]

ulnar nerve MNCV of[MD=4.44

95%CI(0.96

7.91)

P=0.01]

ulnar nerve SNCV of[MD=2.83

95%CI(-0.55

6.21)

(P=0.10)]

tibial nerve MNCV of[MD=4.05

95%CI(3.09

5.01)

P < 0.001]

and tibial nerve SNCV of[MD=4.21

95%CI(2.36

6.07)

P < 0.001]. Conclusion: The effectiveness and safety of Xuefu Zhuyu Tang combined with western medicine in the treatment of DPN in the treatment group is as the same as the control group. But the existing researches need to be verified in more high-quality randomized and double-blind multicenter studies due to their poor quality.