Investigation of Immediate-release Mechanism of Dehydrotrametenolic Acid and Dehydroeburicoic Acid in Poriae Cutis Total Triterpenoids Tablets Based on Liquid-solid Compacts Technique
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Investigation of Immediate-release Mechanism of Dehydrotrametenolic Acid and Dehydroeburicoic Acid in Poriae Cutis Total Triterpenoids Tablets Based on Liquid-solid Compacts Technique
Chinese Journal of Experimental Traditional Medical FormulaeVol. 22, Issue 14, Pages: 14-17(2016)
YAN Xue-sheng, SUN Dan-dan, GUO Yan-wei, et al. Investigation of Immediate-release Mechanism of Dehydrotrametenolic Acid and Dehydroeburicoic Acid in Poriae Cutis Total Triterpenoids Tablets Based on Liquid-solid Compacts Technique[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(14): 14-17.
DOI:
YAN Xue-sheng, SUN Dan-dan, GUO Yan-wei, et al. Investigation of Immediate-release Mechanism of Dehydrotrametenolic Acid and Dehydroeburicoic Acid in Poriae Cutis Total Triterpenoids Tablets Based on Liquid-solid Compacts Technique[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(14): 14-17. DOI: 10.13422/j.cnki.syfjx.2016140014.
Investigation of Immediate-release Mechanism of Dehydrotrametenolic Acid and Dehydroeburicoic Acid in Poriae Cutis Total Triterpenoids Tablets Based on Liquid-solid Compacts Technique
Objective: To investigate the mechanism of improving dissolution of dehydrotrametenolic acid and dehydroeburicoic acid in Poriae Cutis total triterpenoids tablets by liquid-solid compacts technique. Method: Taking dissolution of dehydrotrametenolic acid and dehydroeburicoic acid as indexes
difference of dissolution between liquid-solid compressed tablets and crude drug of total triterpenoids in Poriae Cutis was compared
crude drug
liquid-solid compacts tablets powder and excipients were characterized by differential scanning calorimetry (DSC). Result: Liquid-solid compacts technique could significantly improve dissolution of dehydrotrametenolic acid and dehydroeburicoic acid.Total dissolution of these two ingredients in liquid-solid compressed tablets was 92% at 120 min
total dissolution of them in crude drug was 29% at 120 min.DSC showed that characteristic peaks of drug in liquid-solid tablets had vanished
and suggested that drugs may be present in liquid-solid compressed tablets as amorphous substance. Conclusion: Liquid-solid compacts technique can increase dissolution of total triterpenoids in Poriae Cutis and allow rapid release of poorly soluble drugs.