Investigation of  Transdermal Absorption of Main Ingredients in Qingfei Tongluo Paste

ZHANG Xiu-ying; WANG Xue-feng; LIU Li

doi:10.13422/j.cnki.syfjx.2016140031

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Investigation of Transdermal Absorption of Main Ingredients in Qingfei Tongluo Paste

更新时间：2024-01-04

- Investigation of Transdermal Absorption of Main Ingredients in Qingfei Tongluo Paste
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 14, Pages: 31-34(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016140031
  CLC： R283.6
- Published：2016
- 稿件说明：
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ZHANG Xiu-ying, WANG Xue-feng, LIU Li. Investigation of Transdermal Absorption of Main Ingredients in Qingfei Tongluo Paste[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(14): 31-34.
DOI：

ZHANG Xiu-ying, WANG Xue-feng, LIU Li. Investigation of Transdermal Absorption of Main Ingredients in Qingfei Tongluo Paste[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(14): 31-34. DOI： 10.13422/j.cnki.syfjx.2016140031.

摘要

目的：研究清肺通络膏中大黄游离蒽醌类成分的体外透皮吸收特性，考察辅药大蒜对各成分透皮特性的影响。方法：以清肺通络膏中主要成分芦荟大黄素、大黄素、大黄酸为指标，采用体外透皮吸收试验及HPLC考察该制剂的体外透皮特性，并评价该制剂不同配伍组中指标性成分的累积透过量及渗透速率。结果：大黄素的单位面积累积透皮量及透皮速率最大，芦荟大黄素次之，大黄酸最小；大黄酸的透皮时滞最长（0.419h），大黄素时滞最短（0.006h）；清肺通络膏中大黄素、大黄酸、芦荟大黄素的体外经皮渗透曲线分别为Q=12.144t-14.880（r=0.97），Q=10.111t-3.886（r=0.93），Q=1.389t-0.583（r=0.95）。全方组中大黄素、芦荟大黄素、大黄酸的8h累积透过量为分别为（86.059±0.168），（83.079±3.303），（12.819±0.569）μg·cm-2，透皮速率分别为12.144，10.111，1.389μg·cm-2·h-1，与主药组比较有显著性差异（P<0.05）。结论：清肺通络膏的体外经皮渗透符合零级动力学过程，大蒜对清肺通络膏中指标性成分的经皮渗透有促进作用。

Abstract

Objective: To study in vitro transdermal absorption characteristics of main ingredients in Qingfei Tongluo paste (QFTLP) and investigate effect of different compatibility on transdermal characteristics of main ingredients. Method: Taking main ingredients in QFTLP as indexes

such as aloe-emodin

emodin

rhein

studies were carried out by in vitro transdermal absorption test and HPLC.In vitro transdermal properties of QFTLP was investigated

cumulative transdermal amount per unit area and transdermal rate were evaluated. Result: Cumulative transdermal amount per unit area and transdermal rate of emodin was the largest

followed by aloe-emodin

and rhein was the least.Transdermal time-lag of rhein was the longest (0.419 h)

emodin was the shortest (0.006 h).Penetration curve equations of emodin

aloe-emodin and rhein in QFTLP were Q=12.144t-14.880 (r=0.97)

Q=10.111t-3.886 (r=0.93)

Q=1.389t-0.583 (r=0.95).In overall prescription group

accumulation permeation amounts of emodin

aloe-emodin and rhein in 8 h were (86.059±0.168)

(83.079+3.303)

(12.819+0.569) μg · cm-2

transdermal rates were 12.144

10.111

1.389 μg · cm-2 · h-1

respectively;they had significant difference (P<0.05) by comparing with main formula group. Conclusion: In vitro percutaneous penetration of QFTLP complies with zero-order kinetics.Adjuvant compatibility can promote transdermal absorption of main ingredients.

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Related Institution

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Affiliated Hospital of Nanjing University of Chinese Medicine

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