Objective: To isolate and identify the chemical compounds from the residues in the pulps of Persea americana

and evaluate the capacity of scavenging free radicals of phenolic compounds. Method: The chemical compounds were isolated and purified by the combined normal pressure column chromatography and high pressure liquid preparative chromatography

and their chemical structures were elucidated by spectral data analysis and comparing with the previous literature. Moreover

the capacity of scavenging free radicals of phenolic compounds was also evaluated by using 1

1 diphenyl - 2 - trinitrobenzene hydrazine (DPPH ·) assay. Result: Seven compounds were obtained and their structures were identified as 1

2

4-trihydroxyheptadec-16-yne (1)

1

2

4-trihydroxynonadecane (2)

(2R

12Z

15Z)-2-hydroxy-4-oxoheneicosa-12

15-dien-1-yl acetate (3)

tryptophan (4)

chlorogenic acid (5)

neochlorogenic acid (6)

and scopolin (7) respectively. The in vitro free radicals scavenging activity experiment showed that the capacity of scavenging free radicals of compounds 5 and 6 were close to that of vitamin C. Conclusion: Compounds 4

6 and 7 were isolated from P.americana for the first time. In addition

phenolic compounds obtained from P. americana had good in vitro free radicals scavenging activities.