XU Li-ying, YAO Min, YU Hua, et al. Effect of Yougui Capsule on Osteoporosis in Ovariectomized Rats[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(14): 151-154.
DOI:
XU Li-ying, YAO Min, YU Hua, et al. Effect of Yougui Capsule on Osteoporosis in Ovariectomized Rats[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(14): 151-154. DOI: 10.13422/j.cnki.syfjx.2016140151.
Effect of Yougui Capsule on Osteoporosis in Ovariectomized Rats
Objective: To observe the effects of Yougui capsule on osteoporosis in ovariectomized rats. Method: A total of 105 SPF-grade SD rats were selected
in which 15 were used in the sham-operated group
and the remaining were ovariectomized to reproduce the model of osteoporosis. The ovariectomized rats were divided into model group
Yougui capsule low
medium and high-dose groups (0.71
1.43
2.85 g · kg-1)
estrogen group (diethylstilbestrol
0.02 mg · kg-1) and Xianling Gubao capsule group (0.25 g · kg-1)
with 15 rats in each group. The rats were given the corresponding drugs on the 7th day after surgery for six months. Orbital blood in rats was collected to determine Ca
P
alkaline phosphatase(ALP)
acid phosphatase(ACP) in serum. Right and left thighbones of the rats were collected to determine bone mineral density(BMD)
bone mineral(BMC) with dual energy X-ray absorptiometry. WDW electronic universal testing machine was used to determine mechanical performance indexes of the right thighbone
such as deflection
maximum force and bending strength. Result: Compared with the sham-operated group
the model group showed significant increases in Ca
P
ALP
ACP levels in serum
and decreases in BMD
BMC and bone biomechanical indexes(P<0.05
P<0.01); compared with the model group
Yougui capsule groups can significantly decrease Ca
P
ALP
ACP level in serum
and increase BMD
BMC and bone biomechanical indexes(P<0.05
P<0.01). Conclusion: Yougui capsule can improve biomechanical indexes of ovariectomized rats
and delay the rat bone mass loss
suggesting that Yougui capsule has the preventive effect on osteoporosis.
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Related Author
WEI Di
ZHANG Weiqi
MO Qiong
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QIN Wenhui
Xu YANG
Huaxin WANG
Qian ZHANG
Related Institution
School of Pharmacy, Guangxi University of Chinese Medicine
Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine
The First Affiliated Hospital of Guangxi University of Chinese Medicine
Guilin People's Hospital
Shandong University of Traditional Chinese Medicine(TCM)