Objective: To investigate the possible toxic reactions of Artemisinin and Piperaquine tablets in rhesus monkeys by oral administration

and evaluate its safety. Method: Approximate lethal dose method was used for the experiment. Artemisinin and Piperaquine tablet was given to 5 rhesus monkeys at the doses of 168

377

849

1 910

4 296 mg · kg-1 respectively. Animals were observed with a period of 14 days for the toxic reactions and death. Their body weight

food intake

haematology and blood biochemistry indexes were measured

and gross pathological observation was conducted after anatomy in all rhesus monkeys

in order to calculate the range of approximate lethal dose. Result: No death appeared during 14 days observation. Vomiting and food intake reduction appeared in doses of 4 296

1 910 mg · kg-1

and decrease in body weight was observed in monkey at the dose of 4 296 mg · kg-1. Conclusion: Approximate lethal dose of Artemisinin and Piperaquine tablets is greater than 4 296 mg · kg-1 (equivalent to 257 times of clinical dose) in rhesus monkeys by oral administration.