Objective: To investigate the clinical efficacy of Bushen Kangshuai (BSKS) tablets for unstable angina pectoris (UAP) and observe its effect on flammatory mediator levels in serum. Method: Sixty UAP patients were randomly assigned to treatment group (30 cases) and control group (30 cases). Patients in control group received routine western medical treatment

while those in treatment group additionally took BSKS tablets. The angina symptom scores

clinical efficacy

angina frequencies

and Global Registry of Acute Coronary Events (GRACE) risk scores were compared between two groups both before and after treatment. The changes in interferon-γ(IFN-γ)

interleukin (IL)-2

tumor necrosis factor-α(TNF-α)

and IL-4 levels in serum were detected in both groups by enzyme-linked immunosorbent assay. Result: The angina symptom scores and angina frequency and duration were improved in both groups after treatment (P<0.05

P<0.01)

and the flammatory mediator levels in serum were significantly reduced in both groups (P<0.05)

the clinical efficacy in treatment group was significantly superior to that in control group (P<0.05). GRACE risk scores were highly correlated with the kidney deficiency syndrome scores of patients. Conclusion: Bushen Kangshuai tablet combined with routine western medicine treatment is an effective way to improve the clinical symptoms and lower the levels of inflammatory mediator in patients with UAP.