Objective: To observe the effect of Yiqi Huoxue Huatan decoction on traditional Chinese medicine (TCM) syndrome scores

blood lipid indicators [total cholesterol (TC)

triglyceride (TG)

high-density lipoprotein cholesterol (HDL-C)

low-density lipoprotein cholesterol (LDL-C)]

D-dimer (D-Di)

C-reactive protein (CRP)

intra media thickness (IMT)

ankle brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in aged patients with lower extremity atherosclerotic disease (LEAD). Method: The 66 eligible patients were randomly divided into treatment group (33 cases) and control group (33 cases). Patients in control group were treated with simvastatin tablets (40 mg

qd) and asprin tables (100 mg

qd)

patients in treatment group additionally received Yiqi Huoxue Huatan decoction based on the treatment in control group. Patients were followed up for 12 weeks to observe the changes in TCM symptom scores

blood lipid indicators

D-Di

CRP

IMT

ABI and baPWV before and after treatment. In addition

the hepatic and renal functions were monitored and three routine tests (blood

urine and stool) were conducted. Result: TCM symptom scores in both groups were lower than those before treatment (P<0.05)

and TCM symptom scores in treatment group were lower than those in control group after treatment (P<0.05). LDL-C

D-Di and baPWV levels in both groups were significantly lower than those before treatment (P<0.05)

and the above levels in treatment group were lower than those in control group after treatment (P<0.05). Conclusion: Yiqi Huoxue Huatan decoction combined with simvastatin and asprin can effectively improve the TCM symptom scores

and reduce LDL-C

D-Di and baPWV levels in aged patients with lower extremity atherosclerotic disease (LEAD)

and it may be helpful to improve arterial stiffness.