Objective: To investigate the effect of Bushen Yizhi decoction combined with butylphthalide on glutathione peroxidase (GSH-Px)

amyloid β-protein (Aβ)

superoxide dismutase (SOD) and malondialdehyde (MDA) levels in patients with Alzheimer's disease. Method: The 74 patients with Alzheimer's disease were randomly divided into treatment group (37 cases) and control group (37 cases) according to the random number table method. Patients in control group were treated with oral butylphthalide soft capsule

and patients in treatment group also received Bushen Yizhi decoction based on the treatment in control group

with 12 weeks as a course of treatment. After treatment

minimum mental state examination (MMSE) scale scores

activity of daily living (ADL) scale scores

Aβ

SOD

GSH-Px and MDA levels were compared and analyzed between two groups of patients with Alzheimer's disease. Result: After treatment

the MMSE and ADL scores of both groups were significantly improved (P<0.05)

the degree of improvement in treatment group was more obvious (P<0.05). After treatment

the levels of Aβ in both groups were significantly decreased (P<0.05)

the extent of the reduction in the treatment group was more obvious (P<0.05)

SOD and GSH-Px levels in both groups were significantly increased after treatment (P<0.05)

and the extent of increase in the treatment group was more obvious (P<0.05). The level of MDA in the treatment group was significantly decreased after treatment

and it was lower than that of the control group after treatment (P<0.05). Conclusion: Bushen Yizhi decoction combined with butylphthalide can improve the cognition impairment and the function of the body's resistance to oxidative stress

thus significantly improving the self-care ability and their ability of learning and memory for the patients

so it is worthy of further promotion.