Objective: To investigate the short-term and long-term effects of Jiaogulan Kangai decoction combined with dialectical synchronous chemoradiotherapy and maintenance treatment in treating middle and advanced stage non-small-cell lung cancer (NSCLC). Method: One hundred and seven patients with middle and advanced stage NSCLC were randomly divided into control group (52 cases) and observation group (55 cases) according to their admission sequence. Patients in control group received docetaxel plus cisplatin (TP) method. Based on the treatment of control group

patients in observation group also received dialectical Jiaogulan Kangai decoction

1 dose/day. The observation was stopped until progressive disease appeared. Before and one month after chemotherapy

size of solid tumor was detected by CT. Karnofsky scores were graded for quality of life

and main signs and symptoms were graded. Levels of T-lymphocyte cell subsets and natural killer (NK) cells were detected. Progression free survival (PFS) was recorded and safety was evaluated. Result: The total effective rate was 72.73% in observation group

higher than 53.85% in control group (P<0.05). PFS was (8.1±1.6) months in observation group

superior to (5.4±1.5) months in control group (P<0.01). After treatment

the scores of main signs and symptoms in observation group were lower than those in control group

while scores of Karnofsky were higher than those in control group (P<0.01). The improvement of quality of life and index of stability in observation group was 87.27% in observation group

higher than 71.15% in control group (P<0.05). After treatment

levels of CD3+

CD4+

CD4+/CD8+ and NK in observation were increased as compared with the levels before treatment (P<0.01)

and they were higher than those in control group (P<0.01). Level of CD8+ in observation group was decreased after treatment (P<0.01) and it was lower than that in control group (P<0.05). The incidence of Ⅲ and Ⅳ degree adverse effect in chemotherapeutic period was 21.82% in observation group

lower than 40.38% in control group (P<0.05). Conclusion: Jiaogulan Kangai decoction combined with dialectical synchronous chemoradiotherapy and maintenance treatment can shrink the size of solid tumor

relieve toxic and side effect of chemoradiotherapy

ameliorate clinical symptoms

improve patients' quality of life and immunity

and prolong progression free survival in the treatment of non-small-cell lung cancer

with obvious short-term and long-term efficacy.