Preparation and Dissolution Evaluation of Solid Dispersions of Total Quinones from Rubiae Radix et Rhizoma

PU Yi-qiong; MIAO Kai-ming; WANG Bing; ZHANG Tong; TAO Jian-sheng

doi:10.13422/j.cnki.syfjx.2016150009

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Preparation and Dissolution Evaluation of Solid Dispersions of Total Quinones from Rubiae Radix et Rhizoma

更新时间：2024-09-23

- Preparation and Dissolution Evaluation of Solid Dispersions of Total Quinones from Rubiae Radix et Rhizoma
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 15, Pages: 9-13(2016)
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- DOI：10.13422/j.cnki.syfjx.2016150009
  CLC： R283.6
- Published：2016
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PU Yi-qiong, MIAO Kai-ming, WANG Bing, et al. Preparation and Dissolution Evaluation of Solid Dispersions of Total Quinones from Rubiae Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(15): 9-13.
DOI：

PU Yi-qiong, MIAO Kai-ming, WANG Bing, et al. Preparation and Dissolution Evaluation of Solid Dispersions of Total Quinones from Rubiae Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(15): 9-13. DOI： 10.13422/j.cnki.syfjx.2016150009.

摘要

目的：制备茜草总醌固体分散体并考察其体外溶出性能。方法：采用溶剂-熔融法和溶剂法制备茜草总醌固体分散体，考察不同型号辅料对该固体分散体制备工艺的影响，分别以体外溶出度和溶解度为指标，确定该固体分散体的最优处方。结果：最佳处方为聚乙烯吡咯烷酮S-630-茜草总醌提取物（5∶1），采用溶剂法制备茜草总醌固体分散体，所得产物在1%十二烷基硫酸钠中的溶解度285.39 mg·L-1，为原料的3.6倍；60 min体外累积溶出度66.37%，约为原料的2倍。结论：该工艺制备的固体分散体性状良好，较好地改善了茜草总醌的溶解度，为以茜草为原料的相关固体制剂的开发提供参考。

Abstract

Objective: To prepare solid dispersions of total quinones from Rubiae Radix et Rhizoma and evaluate its in vitro dissolution ability. Method: This solid dispersions was prepared by solvent-melting method and solvent method.Effect of different matrix on preparation technology were investigated

with solubility and in vitro dissolution performance as indexes

optimal formulation was confirmed. Result: This solid dispersions was prepared by solvent method

its optimal formulation was ratio of polyvinyl pyrrolidone (PVP) S-630 and total quinones extract of Rubiae Radix et Rhizoma of 5:1.Solubility of this solid dispersions in 1%sodium dodecyl sulfate (SDS) were increased to 285.39 mg·L-1

in vitro cumulative dissolution within 60 min was 66.37%. Conclusion: The prepared product has good characteristics

which is confirmed to enhance the solubility of total quinones extract of Rubiae Radix et Rhizoma.It can provide a reference for the development of solid preparation originated from Rubiae Radix et Rhizoma.

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