HAN Xiao-jing, FAN Ma-li, QIN Xue-mei, et al. Effect of Scutellariae Radix on Metabolism in Mice by Metabolomics[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(15): 85-91.
DOI:
HAN Xiao-jing, FAN Ma-li, QIN Xue-mei, et al. Effect of Scutellariae Radix on Metabolism in Mice by Metabolomics[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(15): 85-91. DOI: 10.13422/j.cnki.syfjx.2016150085.
Effect of Scutellariae Radix on Metabolism in Mice by Metabolomics
Objective: To investigate effect of Scutellariae Radix on endogenous metabolites in the serum and liver of normal mice based on metabolomics. Method: 1H-NMR based on metabolomics
coupled with multivariate and univariate statistical analysis
was used to compare differential endogenous metabolites in the serum and liver between the normal mice and those treated by Scutellariae Radix. Result: Endogenous metabolism of mice treated by Scutellariae Radix had significant changes.Compared with the blank group
contents of 10 kinds of metabolites in serum had changed
contents of 3-hydroxybutyric acid
citric acid and choline increased
levels of α-glucose and β-glucose decreased in mice serum of Scutellariae Radix group;19 kinds of metabolites in the mice liver of Scutellariae Radix group also changed
levels of glutamic acid
isoleucine and leucine increased
levels of xanthine decreased.Changes of these metabolites in mice of Scutellariae Radix group involved in glycometabolism
lipid metabolism and amino acid metabolism. Conclusion: Impact of Scutellariae Radix on metabolism of mice is related with the cold property of Scutellariae Radix
its anti-oxidative
hepatoprotective and hypoglycemic effect and other pharmacological action.This study can provide a reference for the further research of property and pharmacological mechanism of Scutellariae Radix.
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